Technology Process of N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide
There total 6 articles about N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzyl-thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide;
With
trifluoroacetic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 18h;
With
ammonia;
In
methanol;
for 0.333333h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 1,2-dimethoxyethane / 10 h / Reflux
2.1: sodium hydride / tetrahydrofuran; 2-methyltetrahydrofuran; mineral oil / 20.33 h / 0 - 20 °C
3.1: XPhos; tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 18 h / 0 - 20 °C
4.2: 0.33 h
With
tris-(dibenzylideneacetone)dipalladium(0); N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; potassium carbonate; trifluoroacetic acid; XPhos; trichlorophosphate;
In
tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium acetate / acetonitrile; water / 22 h / 20 °C
2.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 1,2-dimethoxyethane / 10 h / Reflux
3.1: sodium hydride / tetrahydrofuran; 2-methyltetrahydrofuran; mineral oil / 20.33 h / 0 - 20 °C
4.1: XPhos; tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 18 h / 0 - 20 °C
5.2: 0.33 h
With
tris-(dibenzylideneacetone)dipalladium(0); N-benzyl-N,N,N-triethylammonium chloride; sodium acetate; sodium hydride; potassium carbonate; trifluoroacetic acid; XPhos; trichlorophosphate;
In
tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; mineral oil;
