N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide

Base Information

Chemical Name:N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide
CAS No.:1418112-77-2
Molecular Formula:C₁₉H₂₅FN₄O₅S₂
Molecular Weight:472.562
Hs Code.:

Synonyms:N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide

Suppliers and Price of N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide

There total 6 articles about N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418112-80-7
N-(6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzyl-thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide

: 1418112-77-2
N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide

Guidance literature:: N-(6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzyl-thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 18h;

With ammonia; In methanol; for 0.333333h;

Reference yield:

: 401581-40-6
2-(4-fluorobenzylthio)pyrimidine-4,6-diol

: 1418112-77-2
N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 1,2-dimethoxyethane / 10 h / Reflux

2.1: sodium hydride / tetrahydrofuran; 2-methyltetrahydrofuran; mineral oil / 20.33 h / 0 - 20 °C

3.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 18 h / 0 - 20 °C

4.2: 0.33 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; potassium carbonate; trifluoroacetic acid; XPhos; trichlorophosphate; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; mineral oil;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1418112-77-2
N-(6-{[(2R,3S)-3,4-dihydroxy-2-butanyl]oxy}-2-[(4-fluorobenzyl)sulfanyl]-4-pyrimidinyl)-3-methyl-1-azetidinesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium acetate / acetonitrile; water / 22 h / 20 °C

2.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 1,2-dimethoxyethane / 10 h / Reflux

3.1: sodium hydride / tetrahydrofuran; 2-methyltetrahydrofuran; mineral oil / 20.33 h / 0 - 20 °C

4.1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 18 h / 0 - 20 °C

5.2: 0.33 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-benzyl-N,N,N-triethylammonium chloride; sodium acetate; sodium hydride; potassium carbonate; trifluoroacetic acid; XPhos; trichlorophosphate; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; mineral oil;