{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,3]triazol-1-yl]-biphenyl-4-yl}-acetic acid ethyl ester

Base Information

Chemical Name:{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,3]triazol-1-yl]-biphenyl-4-yl}-acetic acid ethyl ester
CAS No.:1396007-95-6
Molecular Formula:C₂₈H₂₈N₄O₄
Molecular Weight:484.555
Hs Code.:

Synonyms:{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,3]triazol-1-yl]-biphenyl-4-yl}-acetic acid ethyl ester

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Chemical Property of {4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,3]triazol-1-yl]-biphenyl-4-yl}-acetic acid ethyl ester

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Technology Process of {4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,3]triazol-1-yl]-biphenyl-4-yl}-acetic acid ethyl ester

There total 5 articles about {4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,3]triazol-1-yl]-biphenyl-4-yl}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.1%

: 859169-20-3
1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester

: 1396007-93-4
[3-(4-bromo-phenyl)-5-methyl-3H-[1,2,3]triazol-4-yl]-carbamic acid (R)-1-phenyl-ethyl ester

: 1396007-95-6
{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,3]triazol-1-yl]-biphenyl-4-yl}-acetic acid ethyl ester

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In water; toluene; at 100 ℃; for 6h; Inert atmosphere;

Reference yield:

: 5467-74-3
4-Bromophenylboronic acid

: 1396007-95-6
{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,3]triazol-1-yl]-biphenyl-4-yl}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide; copper diacetate / methanol / 23 h / 20 °C

2: toluene / 4.5 h / 150 °C

3: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

4: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 65 °C / Inert atmosphere

5: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / toluene; water / 6 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; sodium azide; diphenyl phosphoryl azide; water; copper diacetate; palladium diacetate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; water; toluene; 5: |Suzuki Coupling;

Reference yield:

: 2101-88-4
1-azido-4-bromobenzene

: 1396007-95-6
{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-[1,2,3]triazol-1-yl]-biphenyl-4-yl}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 4.5 h / 150 °C

2: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

3: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 65 °C / Inert atmosphere

4: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / toluene; water / 6 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; diphenyl phosphoryl azide; water; palladium diacetate; triethylamine; lithium hydroxide; In tetrahydrofuran; water; toluene; 4: |Suzuki Coupling;