ethyl 3-((tert-butoxycarbonyl)amino)-2-[(3-(4-methoxyphenyl)-2-methylisothioureido)methyl]acrylate

Base Information

Chemical Name:ethyl 3-((tert-butoxycarbonyl)amino)-2-[(3-(4-methoxyphenyl)-2-methylisothioureido)methyl]acrylate
CAS No.:1351335-15-3
Molecular Formula:C₂₀H₂₉N₃O₅S
Molecular Weight:423.533
Hs Code.:

Synonyms:ethyl 3-((tert-butoxycarbonyl)amino)-2-[(3-(4-methoxyphenyl)-2-methylisothioureido)methyl]acrylate

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Chemical Property of ethyl 3-((tert-butoxycarbonyl)amino)-2-[(3-(4-methoxyphenyl)-2-methylisothioureido)methyl]acrylate

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Technology Process of ethyl 3-((tert-butoxycarbonyl)amino)-2-[(3-(4-methoxyphenyl)-2-methylisothioureido)methyl]acrylate

There total 4 articles about ethyl 3-((tert-butoxycarbonyl)amino)-2-[(3-(4-methoxyphenyl)-2-methylisothioureido)methyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1290128-74-3
1-tert-butyl 5-ethyl 2-methylsulfanyl-1,4-dihydropyrimidine-1,5-dicarboxylate

: 104-94-9
4-methoxy-aniline

: 1351335-15-3
ethyl 3-((tert-butoxycarbonyl)amino)-2-[(3-(4-methoxyphenyl)-2-methylisothioureido)methyl]acrylate

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.10.130

Reference yield: 80.0%

: 1290128-74-3
1-tert-butyl 5-ethyl 2-methylsulfanyl-1,4-dihydropyrimidine-1,5-dicarboxylate

: 104-94-9
4-methoxy-aniline

: 1351335-15-3
ethyl 3-((tert-butoxycarbonyl)amino)-2-[(3-(4-methoxyphenyl)-2-methylisothioureido)methyl]acrylate

: C₁₄H₁₇N₃O₃

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 24h; Reflux;
DOI:10.1016/j.tetlet.2020.152760

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1351335-15-3
ethyl 3-((tert-butoxycarbonyl)amino)-2-[(3-(4-methoxyphenyl)-2-methylisothioureido)methyl]acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / Inert atmosphere

2: pyridinium p-toluenesulfonate / dichloromethane / 6 h / 20 °C / Inert atmosphere

With pyridinium p-toluenesulfonate; sodium hydride; In dichloromethane;
DOI:10.1016/j.tetlet.2011.10.130