cis- and trans-(E)-4-(4-fluorophenyl)-1-(4-phenyl-4-{[3,5-bis(trifluoromethyl)phenyl]-prop-1-enyl}cyclohexyl)piperidine

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Chemical Name:cis- and trans-(E)-4-(4-fluorophenyl)-1-(4-phenyl-4-{[3,5-bis(trifluoromethyl)phenyl]-prop-1-enyl}cyclohexyl)piperidine
CAS No.:374901-76-5
Molecular Formula:C₃₄H₃₄F₇N
Molecular Weight:589.639
Hs Code.:

Synonyms:cis- and trans-(E)-4-(4-fluorophenyl)-1-(4-phenyl-4-{[3,5-bis(trifluoromethyl)phenyl]-prop-1-enyl}cyclohexyl)piperidine

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Chemical Property of cis- and trans-(E)-4-(4-fluorophenyl)-1-(4-phenyl-4-{[3,5-bis(trifluoromethyl)phenyl]-prop-1-enyl}cyclohexyl)piperidine

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Technology Process of cis- and trans-(E)-4-(4-fluorophenyl)-1-(4-phenyl-4-{[3,5-bis(trifluoromethyl)phenyl]-prop-1-enyl}cyclohexyl)piperidine

There total 6 articles about cis- and trans-(E)-4-(4-fluorophenyl)-1-(4-phenyl-4-{[3,5-bis(trifluoromethyl)phenyl]-prop-1-enyl}cyclohexyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37656-48-7
4-(4-fluorophenyl)piperidine

: 374823-23-1
(E)-4-phenyl-4-{3-[3,5-bis(trifluoromethyl)phenyl]prop-1-enyl}cyclohexanone

: 374901-76-5
cis- and trans-(E)-4-(4-fluorophenyl)-1-(4-phenyl-4-{[3,5-bis(trifluoromethyl)phenyl]-prop-1-enyl}cyclohexyl)piperidine

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1016/S0960-894X(02)00249-4

Reference yield:

: 93427-28-2
3,5-Bis(trifluoromethyl)-β-phenethyl alcohol

: 374901-76-5
cis- and trans-(E)-4-(4-fluorophenyl)-1-(4-phenyl-4-{[3,5-bis(trifluoromethyl)phenyl]-prop-1-enyl}cyclohexyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: Bu₃P / tetrahydrofuran / 20 °C

2: OXONE(R); Al₂O₃ / CHCl₃ / Heating

3: LIHMDS / tetrahydrofuran / -78 - 20 °C

4: aq. HCl / acetone / Heating

5: NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

With hydrogenchloride; aluminum oxide; oxone; tributylphosphine; sodium tris(acetoxy)borohydride; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform; 1,2-dichloro-ethane; acetone; 3: Julia coupling;
DOI:10.1016/S0960-894X(02)00249-4

Reference yield:

: 374822-44-3
2-({2-[3,5-bis(trifluoromethyl)phenyl]ethyl}thio)benzothiazole

: 374901-76-5
cis- and trans-(E)-4-(4-fluorophenyl)-1-(4-phenyl-4-{[3,5-bis(trifluoromethyl)phenyl]-prop-1-enyl}cyclohexyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: OXONE(R); Al₂O₃ / CHCl₃ / Heating

2: LIHMDS / tetrahydrofuran / -78 - 20 °C

3: aq. HCl / acetone / Heating

4: NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

With hydrogenchloride; aluminum oxide; oxone; sodium tris(acetoxy)borohydride; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform; 1,2-dichloro-ethane; acetone; 2: Julia coupling;
DOI:10.1016/S0960-894X(02)00249-4