4-(4-Fluorophenyl)piperidine

Base Information

• Chemical Name: 4-(4-Fluorophenyl)piperidine
• CAS No.: 37656-48-7
• Molecular Formula: C11H14 F N
• Molecular Weight: 179.237
• Hs Code.: 2933599590
• European Community (EC) Number: 672-385-9
• DSSTox Substance ID: DTXSID80374655
• Nikkaji Number: J3.363.239H
• Wikidata: Q72476320
• ChEMBL ID: CHEMBL2021622
• Mol file: 37656-48-7.mol

Synonyms:4-(4-fluorophenyl)piperidine;37656-48-7;4-(4-fluoro-phenyl)-piperidine;PIPERIDINE, 4-(4-FLUOROPHENYL)-;4-(4-fluorophenyl)-piperidine;MFCD03426392;CHEMBL2011558;SCHEMBL240518;4-(4-Fluoro-phenyl)piperidine;4-(4-fluorophenyl) piperidine;CHEMBL2021622;DTXSID80374655;AFYALJSDFPSAAZ-UHFFFAOYSA-N;BCP26697;BDBM50379813;STK500854;AKOS000209030;AB14868;AC-4598;SB18378;BP-11136;DS-13283;A6425;AM20040320;CS-0132044;FT-0630287;EN300-147884;Q-102118

Chemical Property of 4-(4-Fluorophenyl)piperidine

Chemical Property:

• Vapor Pressure: 0.0136mmHg at 25°C
• Boiling Point: 258.6°Cat760mmHg
• PKA: 10.18±0.10(Predicted)
• Flash Point: 110.2°C
• Density: 1.048g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 179.111027613
• Heavy Atom Count: 13
• Complexity: 146

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Fluorophenyl)piperidine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1C2=CC=C(C=C2)F

Technology Process of 4-(4-Fluorophenyl)piperidine

There total 21 articles about 4-(4-Fluorophenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(4-fluorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)pyridine (163630-89-5) → 4-(4-fluorophenyl)piperidine (37656-48-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0960-894X(00)00703-4

Reference yield: 99.0%

4-(4-fluorophenyl)piperidine hydrochloride → 4-(4-fluorophenyl)piperidine (37656-48-7)

Guidance literature:

With sodium carbonate; In water; ethyl acetate;

Reference yield: 95.0%

4-(4-fluorophenyl)-2,6-piperidinedione (163631-01-4) → 4-(4-fluorophenyl)piperidine (37656-48-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1.5h; Heating;

DOI:10.1021/jm00011a019

upstream raw materials:

4-(4-fluorophenyl)-2,6-piperidinedione

4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride

4-(4-fluorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)pyridine

1,2,3,6-tetrahydropyridine