(S)-3-Benzyl-4-((E)-3,3,3-trifluoro-prop-1-ene-1-sulfonyl)-1-oxa-4-aza-spiro[4.5]decane

Base Information

Chemical Name:(S)-3-Benzyl-4-((E)-3,3,3-trifluoro-prop-1-ene-1-sulfonyl)-1-oxa-4-aza-spiro[4.5]decane
CAS No.:220349-79-1
Molecular Formula:C₁₈H₂₂F₃NO₃S
Molecular Weight:389.439
Hs Code.:

Synonyms:(S)-3-Benzyl-4-((E)-3,3,3-trifluoro-prop-1-ene-1-sulfonyl)-1-oxa-4-aza-spiro[4.5]decane

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Chemical Property of (S)-3-Benzyl-4-((E)-3,3,3-trifluoro-prop-1-ene-1-sulfonyl)-1-oxa-4-aza-spiro[4.5]decane

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Technology Process of (S)-3-Benzyl-4-((E)-3,3,3-trifluoro-prop-1-ene-1-sulfonyl)-1-oxa-4-aza-spiro[4.5]decane

There total 4 articles about (S)-3-Benzyl-4-((E)-3,3,3-trifluoro-prop-1-ene-1-sulfonyl)-1-oxa-4-aza-spiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 220349-79-1
(S)-3-Benzyl-4-((E)-3,3,3-trifluoro-prop-1-ene-1-sulfonyl)-1-oxa-4-aza-spiro[4.5]decane

Guidance literature:: Multi-step reaction with 3 steps

1.1: TsOH / benzene

2.1: BuLi / tetrahydrofuran

2.2: NaBH₄ / methanol

3.1: MsCl; Et₃N

With n-butyllithium; toluene-4-sulfonic acid; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; benzene; 1.1: Acetalization / 2.1: Carbonylation / 2.2: Reduction / 3.1: Elimination;
DOI:10.3987/COM-98-S(H)26

Reference yield:

: 220349-81-5
(S)-3-phenyl-2-(methanesulfonyl amino)propan-1-ol

: 220349-79-1
(S)-3-Benzyl-4-((E)-3,3,3-trifluoro-prop-1-ene-1-sulfonyl)-1-oxa-4-aza-spiro[4.5]decane

Guidance literature:: Multi-step reaction with 3 steps

1.1: TsOH / benzene

2.1: BuLi / tetrahydrofuran

2.2: NaBH₄ / methanol

3.1: MsCl; Et₃N

With n-butyllithium; toluene-4-sulfonic acid; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; benzene; 1.1: Acetalization / 2.1: Carbonylation / 2.2: Reduction / 3.1: Elimination;
DOI:10.3987/COM-98-S(H)26

Reference yield:

: 220349-85-9
(S)-3-Benzyl-4-methanesulfonyl-1-oxa-4-aza-spiro[4.5]decane

: 220349-79-1
(S)-3-Benzyl-4-((E)-3,3,3-trifluoro-prop-1-ene-1-sulfonyl)-1-oxa-4-aza-spiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran

1.2: NaBH₄ / methanol

2.1: MsCl; Et₃N

With n-butyllithium; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; 1.1: Carbonylation / 1.2: Reduction / 2.1: Elimination;
DOI:10.3987/COM-98-S(H)26