(3R,4S)-4-((S)-3-Benzyl-1-oxa-4-aza-spiro[4.5]decane-4-sulfonyl)-3-trifluoromethyl-cyclohexanone

Base Information

Chemical Name:(3R,4S)-4-((S)-3-Benzyl-1-oxa-4-aza-spiro[4.5]decane-4-sulfonyl)-3-trifluoromethyl-cyclohexanone
CAS No.:220350-18-5
Molecular Formula:C₂₂H₂₈F₃NO₄S
Molecular Weight:459.53
Hs Code.:

Synonyms:(3R,4S)-4-((S)-3-Benzyl-1-oxa-4-aza-spiro[4.5]decane-4-sulfonyl)-3-trifluoromethyl-cyclohexanone

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Chemical Property of (3R,4S)-4-((S)-3-Benzyl-1-oxa-4-aza-spiro[4.5]decane-4-sulfonyl)-3-trifluoromethyl-cyclohexanone

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Technology Process of (3R,4S)-4-((S)-3-Benzyl-1-oxa-4-aza-spiro[4.5]decane-4-sulfonyl)-3-trifluoromethyl-cyclohexanone

There total 1 articles about (3R,4S)-4-((S)-3-Benzyl-1-oxa-4-aza-spiro[4.5]decane-4-sulfonyl)-3-trifluoromethyl-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 3588-30-5
2-methoxy-1,3-butadiene

: 220349-79-1
(S)-3-Benzyl-4-((E)-3,3,3-trifluoro-prop-1-ene-1-sulfonyl)-1-oxa-4-aza-spiro[4.5]decane

: (S)-3-Benzyl-4-(4-methoxy-6-trifluoromethyl-cyclohex-3-enesulfonyl)-1-oxa-4-aza-spiro[4.5]decane

: (3S,4R)-4-((S)-3-Benzyl-1-oxa-4-aza-spiro[4.5]decane-4-sulfonyl)-3-trifluoromethyl-cyclohexanone

: 220350-18-5
(3R,4S)-4-((S)-3-Benzyl-1-oxa-4-aza-spiro[4.5]decane-4-sulfonyl)-3-trifluoromethyl-cyclohexanone

Guidance literature:: 2-methoxy-1,3-butadiene; (S)-3-Benzyl-4-((E)-3,3,3-trifluoro-prop-1-ene-1-sulfonyl)-1-oxa-4-aza-spiro[4.5]decane; at 100 ℃; under 7500600 Torr;

(S)-3-Benzyl-4-(4-methoxy-6-trifluoromethyl-cyclohex-3-enesulfonyl)-1-oxa-4-aza-spiro[4.5]decane; With hydrogenchloride; In tetrahydrofuran; water; at 25 ℃;
DOI:10.3987/COM-98-S(H)26

Reference yield: 75.0%

: 120-80-9,19481-10-8,37349-32-9
benzene-1,2-diol

: 220350-18-5
(3R,4S)-4-((S)-3-Benzyl-1-oxa-4-aza-spiro[4.5]decane-4-sulfonyl)-3-trifluoromethyl-cyclohexanone

: 182-55-8
spiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]

: (1S,4S,7S,8R)-4-Benzyl-8-trifluoromethyl-2-oxa-6-thia-5-aza-tricyclo[5.2.2.0^1,5]undecane 6,6-dioxide

Guidance literature:: toluene-4-sulfonic acid; In benzene; Heating;
DOI:10.3987/COM-98-S(H)26

Reference yield:

: 220350-18-5
(3R,4S)-4-((S)-3-Benzyl-1-oxa-4-aza-spiro[4.5]decane-4-sulfonyl)-3-trifluoromethyl-cyclohexanone

: (1S,4S,7S,8R)-4-Benzyl-7-methylsulfanyl-8-trifluoromethyl-2-oxa-6-thia-5-aza-tricyclo[5.2.2.0^1,5]undecane 6,6-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / p-TsOH / benzene / Heating

2: 89 percent / BuLi / tetrahydrofuran

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; benzene; 1: Transacetalization / 2: Thioetherification;
DOI:10.3987/COM-98-S(H)26