6-[1-(2,3-Dihydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Chemical Name:6-[1-(2,3-Dihydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one
CAS No.:1221501-39-8
Molecular Formula:C₂₁H₂₀FN₃O₄
Molecular Weight:397.406
Hs Code.:

Synonyms:6-[1-(2,3-Dihydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Chemical Property of 6-[1-(2,3-Dihydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Technology Process of 6-[1-(2,3-Dihydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

There total 6 articles about 6-[1-(2,3-Dihydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1221503-58-7
6-{1-[3-(benzyloxy)-2-oxopropyl]-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl}-2H-1,4-benzoxazin-3(4H)-one

: 1221501-39-8
6-[1-(2,3-Dihydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 - 40 ℃; for 36h; under 760.051 Torr;

Reference yield:

: 1221503-42-9
1-(benzyloxy)-3-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]propan-2-ol

: 1221501-39-8
6-[1-(2,3-Dihydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / toluene / 20 °C / Cooling with ice

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 12 h / Reflux; Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 36 h / 20 - 40 °C / 760.05 Torr

With hydrogen; caesium carbonate; Dess-Martin periodane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

: 29681-98-9
p-fluorobenzoylacetone

: 1221501-39-8
6-[1-(2,3-Dihydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / methanol; water / 20 °C / Cooling with ice

2: N-Bromosuccinimide / acetonitrile / 20 °C / Cooling with ice

3: Dess-Martin periodane / toluene / 20 °C / Cooling with ice

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 12 h / Reflux; Inert atmosphere

5: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 36 h / 20 - 40 °C / 760.05 Torr

With hydrogenchloride; N-Bromosuccinimide; hydrogen; caesium carbonate; Dess-Martin periodane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; toluene; acetonitrile;