1-(benzyloxy)-3-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetone

Base Information

Chemical Name:1-(benzyloxy)-3-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetone
CAS No.:1221503-44-1
Molecular Formula:C₂₀H₁₈BrFN₂O₂
Molecular Weight:417.278
Hs Code.:

Synonyms:1-(benzyloxy)-3-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(benzyloxy)-3-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetone

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Technology Process of 1-(benzyloxy)-3-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetone

There total 6 articles about 1-(benzyloxy)-3-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1221503-42-9
1-(benzyloxy)-3-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]propan-2-ol

: 1221503-44-1
1-(benzyloxy)-3-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetone

Guidance literature:: With Dess-Martin periodane; In toluene; at 20 ℃; for 12h; Cooling with ice;
DOI:10.1016/j.bmc.2014.07.038

Reference yield:

: 2930-05-4
Benzyloxymethyl-oxiran

: 1221503-44-1
1-(benzyloxy)-3-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetone

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / 3 h / 60 °C

2: hydrogenchloride / water; methanol / 12 h / 20 °C / Cooling with ice

3: N-Bromosuccinimide / acetonitrile / 0.17 h / 20 °C

4: Dess-Martin periodane / toluene / 12 h / 20 °C / Cooling with ice

With hydrogenchloride; N-Bromosuccinimide; Dess-Martin periodane; hydrazine hydrate; In methanol; water; toluene; acetonitrile; 4: |Dess-Martin Oxidation;
DOI:10.1016/j.bmc.2014.07.038

Reference yield:

: 1221503-40-7
1-(benzyloxy)-3-hydrazinopropan-2-ol

: 1221503-44-1
1-(benzyloxy)-3-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; methanol / 12 h / 20 °C / Cooling with ice

2: N-Bromosuccinimide / acetonitrile / 0.17 h / 20 °C

3: Dess-Martin periodane / toluene / 12 h / 20 °C / Cooling with ice

With hydrogenchloride; N-Bromosuccinimide; Dess-Martin periodane; In methanol; water; toluene; acetonitrile; 3: |Dess-Martin Oxidation;
DOI:10.1016/j.bmc.2014.07.038