(-)-(Z,2S,3R)-3-(isopropyl)-5-phenyl-5-(triethylsilyl)pent-4-en-2-ol

Base Information

• Chemical Name: (-)-(Z,2S,3R)-3-(isopropyl)-5-phenyl-5-(triethylsilyl)pent-4-en-2-ol
• CAS No.: 1058213-77-6
• Molecular Formula: C₂₀H₃₄OSi
• Molecular Weight: 318.575
• Mol file: 1058213-77-6.mol

Synonyms:(-)-(Z,2S,3R)-3-(isopropyl)-5-phenyl-5-(triethylsilyl)pent-4-en-2-ol

Chemical Property of (-)-(Z,2S,3R)-3-(isopropyl)-5-phenyl-5-(triethylsilyl)pent-4-en-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(Z,2S,3R)-3-(isopropyl)-5-phenyl-5-(triethylsilyl)pent-4-en-2-ol

There total 3 articles about (-)-(Z,2S,3R)-3-(isopropyl)-5-phenyl-5-(triethylsilyl)pent-4-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C21H37NO2SSi (1058213-69-6) + phenyllithium (591-51-5) → (Z,2S,3R)-3-isopropyl-5-phenylpent-4-en-2-ol (1058213-83-4) + (E,2S,3R)-3-isopropyl-5-phenylpent-4-en-2-ol (1058213-82-3) + (-)-(Z,2S,3R)-3-(isopropyl)-5-phenyl-5-(triethylsilyl)pent-4-en-2-ol (1058213-77-6) + (4E,6E,2S,3R,8SR,9S)-3,8-diisopropyl-5-phenyldeca-4,6-diene-2,9-diol

Guidance literature:

C₂₁H₃₇NO₂SSi; phenyllithium; With copper(l) iodide; In diethyl ether; cyclohexane; at -15 - 0 ℃; for 5h; Inert atmosphere;

With ammonia; water; ammonium chloride; In diethyl ether; cyclohexane; at 0 ℃; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 60h; optical yield given as %de; Inert atmosphere;

DOI:10.1002/chem.200800455

Reference yield: 74.0%

C21H37NO2SSi (1058213-69-6) + phenyllithium (591-51-5) → C20H34OSi + (-)-(Z,2S,3R)-3-(isopropyl)-5-phenyl-5-(triethylsilyl)pent-4-en-2-ol (1058213-77-6) + (7E,9E,5S,6R,12S)-3,3,14,14-tetraethyl-6,11-diisopropyl-5,12-dimethyl-8-phenyl-4,13-dioxa-3,14-disilahexadeca-7,9-diene

Guidance literature:

C₂₁H₃₇NO₂SSi; phenyllithium; With copper(l) iodide; In diethyl ether; cyclohexane; at -15 - 0 ℃; for 5h; Inert atmosphere;

With ammonia; water; ammonium chloride; In diethyl ether; cyclohexane; at 0 ℃; Inert atmosphere;

DOI:10.1002/chem.200800455

Reference yield: 74.0%

C21H37NO2SSi (1058213-69-6) + phenyllithium (591-51-5) → triethyl (Z,2S,3R)-(3-isopropyl-5-phenylpent-4-en-2-yloxy)silane (1058213-80-1) + triethyl (E,2S,3R)-(3-isopropyl-5-phenylpent-4-en-2-yloxy)silane (1058213-78-7) + (-)-(Z,2S,3R)-3-(isopropyl)-5-phenyl-5-(triethylsilyl)pent-4-en-2-ol (1058213-77-6) + (7E,9E,5S,6R,12S)-3,3,14,14-tetraethyl-6,11-diisopropyl-5,12-dimethyl-8-phenyl-4,13-dioxa-3,14-disilahexadeca-7,9-diene

Guidance literature:

C₂₁H₃₇NO₂SSi; phenyllithium; With copper(l) iodide; In diethyl ether; at -15 - 20 ℃; for 3h; Inert atmosphere;

With ammonia; water; ammonium chloride; In diethyl ether; optical yield given as %de; Inert atmosphere;

DOI:10.1002/chem.200800455

upstream raw materials:

C₂₁H₃₇NO₂SSi

phenyllithium