2-(4-fluoro-N-isopropylphenylsulfonamido)-N-((1-(4-(trifluoromethyl)phenyl)pyrrolidin-3-yl)methyl)acetamide

Base Information

Chemical Name:2-(4-fluoro-N-isopropylphenylsulfonamido)-N-((1-(4-(trifluoromethyl)phenyl)pyrrolidin-3-yl)methyl)acetamide
CAS No.:1610505-70-8
Molecular Formula:C₂₃H₂₇F₄N₃O₃S
Molecular Weight:501.545
Hs Code.:

Synonyms:2-(4-fluoro-N-isopropylphenylsulfonamido)-N-((1-(4-(trifluoromethyl)phenyl)pyrrolidin-3-yl)methyl)acetamide

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Chemical Property of 2-(4-fluoro-N-isopropylphenylsulfonamido)-N-((1-(4-(trifluoromethyl)phenyl)pyrrolidin-3-yl)methyl)acetamide

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Technology Process of 2-(4-fluoro-N-isopropylphenylsulfonamido)-N-((1-(4-(trifluoromethyl)phenyl)pyrrolidin-3-yl)methyl)acetamide

There total 4 articles about 2-(4-fluoro-N-isopropylphenylsulfonamido)-N-((1-(4-(trifluoromethyl)phenyl)pyrrolidin-3-yl)methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1178934-09-2
[(4-fluorobenzenesulfonyl)(isopropyl)amino]acetic acid

: 1016805-07-4
[1-(4-trifluoromethylphenyl)pyrrolidin-3-yl]methylamine

: 1610505-70-8
2-(4-fluoro-N-isopropylphenylsulfonamido)-N-((1-(4-(trifluoromethyl)phenyl)pyrrolidin-3-yl)methyl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 25 ℃; for 2h;

Reference yield:

: 402-43-7
p-trifluoromethylphenyl bromide

: 1610505-70-8
2-(4-fluoro-N-isopropylphenylsulfonamido)-N-((1-(4-(trifluoromethyl)phenyl)pyrrolidin-3-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 120 °C / Inert atmosphere; Sealed tube

2: water; hydrogenchloride / ethyl acetate / 2 h / 25 - 50 °C

3: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 25 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; sodium t-butanolate; In dichloromethane; ethyl acetate; toluene;

Reference yield:

: 1610505-79-7
[1-(4-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]carbamic acid tert-butyl ester

: 1610505-70-8
2-(4-fluoro-N-isopropylphenylsulfonamido)-N-((1-(4-(trifluoromethyl)phenyl)pyrrolidin-3-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; hydrogenchloride / ethyl acetate / 2 h / 25 - 50 °C

2: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 25 °C

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; ethyl acetate;