2-cyclopentyl-4-(4-fluorophenyl)-7,7-dimethyl-3-(4-trifluoromethylbenzoyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one

Base Information

• Chemical Name: 2-cyclopentyl-4-(4-fluorophenyl)-7,7-dimethyl-3-(4-trifluoromethylbenzoyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one
• CAS No.: 202263-73-8
• Molecular Formula: C₃₀H₂₉F₄NO₂
• Molecular Weight: 511.559

Synonyms:2-cyclopentyl-4-(4-fluorophenyl)-7,7-dimethyl-3-(4-trifluoromethylbenzoyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one

Chemical Property of 2-cyclopentyl-4-(4-fluorophenyl)-7,7-dimethyl-3-(4-trifluoromethylbenzoyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one

Chemical Property:

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Technology Process of 2-cyclopentyl-4-(4-fluorophenyl)-7,7-dimethyl-3-(4-trifluoromethylbenzoyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one

There total 3 articles about 2-cyclopentyl-4-(4-fluorophenyl)-7,7-dimethyl-3-(4-trifluoromethylbenzoyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-fluorobenzaldehyde (459-57-4) + dimedone (126-81-8) + 3-Amino-3-cyclopentyl-1-(4-trifluoromethylphenyl)-propenone → 2-cyclopentyl-4-(4-fluorophenyl)-7,7-dimethyl-3-(4-trifluoromethylbenzoyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one (202263-73-8)

Guidance literature:

With trifluoroacetic acid;

DOI:10.2533/000942904777678082

Reference yield:

1-(4-trifluoromethylphenyl)ethanone (709-63-7) → 2-cyclopentyl-4-(4-fluorophenyl)-7,7-dimethyl-3-(4-trifluoromethylbenzoyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one (202263-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH; 18-crown-6

1.2: NH₄QAc

2.1: 45 percent / TFA

With 18-crown-6 ether; sodium hydride; trifluoroacetic acid;

DOI:10.2533/000942904777678082

Reference yield:

methyl cyclopentane carboxylate (4630-80-2) → 2-cyclopentyl-4-(4-fluorophenyl)-7,7-dimethyl-3-(4-trifluoromethylbenzoyl)-4,6,7,8-tetrahydro-1H-quinolin-5-one (202263-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH; 18-crown-6

1.2: NH₄QAc

2.1: 45 percent / TFA

With 18-crown-6 ether; sodium hydride; trifluoroacetic acid;

DOI:10.2533/000942904777678082

upstream raw materials:

4-fluorobenzaldehyde

dimedone

1-(4-trifluoromethylphenyl)ethanone

methyl cyclopentane carboxylate

Downstream raw materials:

(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-3-[(S)-fluoro-(4-trifluoromethyl-phenyl)-methyl]-7,7-dimethyl-5,6,7,8-tetrahydro-quinoline

[5-(tert-butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-quinolin-3-yl]-(4-trifluoromethyl-phenyl)-methanone

[(S)-2-Cyclopentyl-4-(4-fluoro-phenyl)-5-hydroxy-7,7-dimethyl-5,6,7,8-tetrahydro-quinolin-3-yl]-(4-trifluoromethyl-phenyl)-methanone

2-cyclopentyl-4-(4-fluorophenyl)-7,7-dimethyl-3-(4-trifluoromethylbenzoyl)-7,8-dihydro-6H-quinolin-5-one

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