Technology Process of 5-(3,5-di-tert-butylphenyl)-2-methyl-1-(piperidin-1-ylsulfonyl)-1H-pyrrole-3-sulfonamide
There total 6 articles about 5-(3,5-di-tert-butylphenyl)-2-methyl-1-(piperidin-1-ylsulfonyl)-1H-pyrrole-3-sulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonia;
In
tetrahydrofuran; dichloromethane;
at -20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide; tetrahydrofuran / 0 - 20 °C
3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / 100 °C
4.1: sodium hydroxide; water / methanol / 3 h / Reflux
4.2: pH 2
5.1: trifluoroacetic acid / 0.5 h / 100 °C
6.1: chlorosulfonic acid / dichloromethane / 48 h / -40 - 20 °C / Inert atmosphere
7.1: ammonia / dichloromethane; tetrahydrofuran / 2 h / -20 °C
With
chlorosulfonic acid; N-Bromosuccinimide; ammonia; water; sodium hydride; sodium carbonate; trifluoroacetic acid; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
3.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / 100 °C
2.1: sodium hydroxide; water / methanol / 3 h / Reflux
2.2: pH 2
3.1: trifluoroacetic acid / 0.5 h / 100 °C
4.1: chlorosulfonic acid / dichloromethane / 48 h / -40 - 20 °C / Inert atmosphere
5.1: ammonia / dichloromethane; tetrahydrofuran / 2 h / -20 °C
With
chlorosulfonic acid; ammonia; water; sodium carbonate; trifluoroacetic acid; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
1.1: Suzuki Coupling;
