(E)-1-(2-((2-methoxyphenyl)sulfonyl)vinyl)-4-trifluoromethylbenzene

Base Information

• Chemical Name: (E)-1-(2-((2-methoxyphenyl)sulfonyl)vinyl)-4-trifluoromethylbenzene
• CAS No.: 1478585-14-6
• Molecular Formula: C₁₆H₁₃F₃O₃S
• Molecular Weight: 342.339
• Mol file: 1478585-14-6.mol

Synonyms:(E)-1-(2-((2-methoxyphenyl)sulfonyl)vinyl)-4-trifluoromethylbenzene

Chemical Property of (E)-1-(2-((2-methoxyphenyl)sulfonyl)vinyl)-4-trifluoromethylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(2-((2-methoxyphenyl)sulfonyl)vinyl)-4-trifluoromethylbenzene

There total 2 articles about (E)-1-(2-((2-methoxyphenyl)sulfonyl)vinyl)-4-trifluoromethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + diethyl (((2-methoxyphenyl)sulfonyl)methyl)phosphonate (83050-86-6) → (E)-1-(2-((2-methoxyphenyl)sulfonyl)vinyl)-4-trifluoromethylbenzene (1478585-14-6)

Guidance literature:

diethyl (((2-methoxyphenyl)sulfonyl)methyl)phosphonate; With n-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h;

4-Trifluoromethylbenzaldehyde; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃; for 1h;

DOI:10.1021/jm401788m

Reference yield:

diethyl (((2-methoxyphenyl)thio)methyl)phosphonate (1478586-05-8) → (E)-1-(2-((2-methoxyphenyl)sulfonyl)vinyl)-4-trifluoromethylbenzene (1478585-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h

2.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

2.2: 1 h / -78 - 20 °C

With n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; cyclohexane;

DOI:10.1021/jm401788m

upstream raw materials:

diethyl (((2-methoxyphenyl)thio)methyl)phosphonate

4-Trifluoromethylbenzaldehyde

diethyl (((2-methoxyphenyl)sulfonyl)methyl)phosphonate