(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-(2-methoxyphenyl)-3-methylisoxazol-4-yl)methanone

Base Information

Chemical Name:(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-(2-methoxyphenyl)-3-methylisoxazol-4-yl)methanone
CAS No.:1362020-30-1
Molecular Formula:C₂₂H₂₁ClN₄O₅
Molecular Weight:456.886
Hs Code.:

Synonyms:(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-(2-methoxyphenyl)-3-methylisoxazol-4-yl)methanone

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Chemical Property of (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-(2-methoxyphenyl)-3-methylisoxazol-4-yl)methanone

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Technology Process of (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-(2-methoxyphenyl)-3-methylisoxazol-4-yl)methanone

There total 5 articles about (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-(2-methoxyphenyl)-3-methylisoxazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

: 1082329-73-4
5-(2-methoxyphenyl)-3-methylisoxazole-4-carboxylic acid

: 114878-60-3
1-(2-chloro-4-nitro-phenyl)piperazine

: 1362020-30-1
(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-(2-methoxyphenyl)-3-methylisoxazol-4-yl)methanone

Guidance literature:: 5-(2-methoxyphenyl)-3-methylisoxazole-4-carboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

1-(2-chloro-4-nitro-phenyl)piperazine; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h; Cooling with ice;
DOI:10.1021/jm2013503

Reference yield:

: 1362020-29-8
C₁₄H₁₅NO₄

: 1362020-30-1
(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-(2-methoxyphenyl)-3-methylisoxazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C

1.2: pH 4

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 3 h / 20 °C / Cooling with ice

With oxalyl dichloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2013503

Reference yield:

: 92252-55-6
ethyl (2-methoxybenzoyl)acetoacetate

: 1362020-30-1
(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-(2-methoxyphenyl)-3-methylisoxazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride / ethanol; water / 60 °C

2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C

2.2: pH 4

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 3 h / 20 °C / Cooling with ice

With oxalyl dichloride; hydroxylamine hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2013503