114878-60-3

Basic information

• Product Name: 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE
• Synonyms: 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE;BUTTPARK 83\09-66;(2-Chloro-4-nitrophenyl)piperazine;1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE >98%;3-Chloro-4-(piperazin-1-yl)nitrobenzene, 2-Chloro-4-nitro-1-(piperazin-1-yl)benzene;BAS 00805288;EU-0035959;MLS000689042
• CAS NO: 114878-60-3
• Molecular Formula: C₁₀H₁₂ClN₃O₂
• Molecular Weight: 241.67
• Product Categories: Amines and Anilines;Heterocycles;Piperaizine;API intermediates;piperazines
• Mol File: 114878-60-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 105 °C
• Boiling Point: 411 °C at 760 mmHg
• Flash Point: 202.4 °C
• Appearance: /Solid
• Density: 1.331 g/cm³
• Vapor Pressure: 5.78E-07mmHg at 25°C
• Refractive Index: 1.589
• PKA: 8.53±0.10(Predicted)
• CAS DataBase Reference: 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE(114878-60-3)
• EPA Substance Registry System: 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE(114878-60-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 114878-60-3(Hazardous Substances Data)

Usage

General Description

1-(2-Chloro-4-nitrophenyl)-piperazine, often abbreviated as CNPP, is a chemical compound containing nitrogen, hydrogen, chlorine, and oxygen. It is widely used in the chemical and pharmaceutical industries, and generally presented as a characteristic yellow crystalline solid. Its molecular formula is C10H12ClN3O2 and it has a molecular weight of 247.68 g/mol. This chemical, like other piperazines, possesses a range of biological activities and may be used in the synthesis of pharmaceutical products. However, there's less information about this specific compound, indicating that it's not as commonly used or well-studied as some other compounds. Overall, handling and usage of this compound should be conducted with proper protective measures, considering potential hazards and toxicity.

InChI:InChI=1/C10H12ClN3O2/c11-9-7-8(14(15)16)1-2-10(9)13-5-3-12-4-6-13/h1-2,7,12H,3-6H2

Upstream product

• 123-91-1 1,4-dioxane 
• 110-85-0 piperazine 
• 99-54-7 3,4-dichloronitrobenzene 

Downstream Products

• 94012-01-8 [4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-(3,5-dibromo-2-hydroxy-phenyl)-methanone 
• 193902-80-6 tert-butyl 4-(2-chloro-4-nitro-phenyl)piperazine-1-carboxylate 
• 354124-99-5 1-(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)-2-methylpropan-1-one 
• 341001-38-5 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-phenylisoxazol-4-yl)methanone 
• 1264870-26-9 C₂₇H₃₃ClN₄O₅Si 
• 1264870-21-4 [4-(2-chloro-4-nitro-pheny1)-piperazin-1-yl]-[3-(4-hydroxy-pheny1)-5-methylisoxazol-4-yl]-methanone 
• 1264870-22-5 [4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-[3-(4-aminophenyl)-5-methylisoxazol-4-yl]methanone 
• 1370420-13-5 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methanone 
• 312537-30-7 [4-(2-chloro-4-nitro-pheny1)-piperazin-1-yl]-[3-(2-chloro-phenyl)-5-methylisoxazol-4-yl]-methanone 
• 1370421-09-2 (4-(4-azido-2-chlorophenyl)piperazin-1-yl)(3-(2-chlorophenyl)-5-methylisoxazol-4-yl)methanone 
• 1370421-10-5 (4-(4-amino-2-chlorophenyl)piperazin-1-yl)(3-(2-chlorophenyl)-5-methylisoxazol-4-yl)methanone 
• 1362020-27-6 biphenyl-2-yl(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)-methanone 
• 1362020-25-4 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(3-methyl-5-phenylisoxazol-4-yl)methanone 
• 1362020-32-3 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(2'-methoxybiphenyl-2-yl)methanone 

Relevant articles and documents

ANTIVIRAL COMPOUNDS AND METHODS OF MAKING AND USING THERE OF CROSS REFERENCE TO RELATED APPLICATIONS

Compounds which exhibit antiviral activity, particularly against influenza virus,and methods of making and using there of are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteralor parenteral administration. The compounds are preferably used to treat or prevent Influenza Ainfections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.

Sulfanyl substituted phenyl methanones

The present invention relates to compounds of formula I wherein R1, R2, R3, X, X1, and n are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (GlyT-1) for the treatment CNS disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.

Studies in Potential Filaricides: Part XV - Synthesis of 1-Acyl/Aryl-4-substituted-piperazines as Diethylcarbamazine Analogs

1-Acyl-4-substituted-piperazines (4-29) have been prepared starting from 1-benzylpiperazine while 1-aryl-4-aroylpiperazines (30-44) have been obtained from the corresponding 1-arylpiperazines.None of the compounds shows any significant filaricidal activity against Litomosoides carinii in cotton rats and cestodicial activity against Hymenolepis nana in mice.