4-(4-Fluorophenyl)-2-(1-methylethyl)-6-(thien-2-yl)-3-pyridinecarboxylic acid,ethyl ester

Base Information

• Chemical Name: 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-(thien-2-yl)-3-pyridinecarboxylic acid,ethyl ester
• CAS No.: 137586-59-5
• Molecular Formula: C₂₁H₂₀FNO₂S
• Molecular Weight: 369.46

Synonyms:4-(4-Fluorophenyl)-2-(1-methylethyl)-6-(thien-2-yl)-3-pyridinecarboxylic acid,ethyl ester

Chemical Property of 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-(thien-2-yl)-3-pyridinecarboxylic acid,ethyl ester

Chemical Property:

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Technology Process of 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-(thien-2-yl)-3-pyridinecarboxylic acid,ethyl ester

There total 5 articles about 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-(thien-2-yl)-3-pyridinecarboxylic acid,ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[1-(4-Fluoro-phenyl)-3-oxo-3-thiophen-2-yl-propyl]-4-methyl-3-oxo-pentanoic acid ethyl ester (137586-58-4) → 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-(thien-2-yl)-3-pyridinecarboxylic acid,ethyl ester (137586-59-5)

Guidance literature:

With copper diacetate; ammonium acetate; In acetic acid; for 24h; Heating;

DOI:10.1021/jm00113a019

Reference yield:

(E)‐3‐(4‐fluorophenyl)‐1‐(thiophen‐2‐yl)prop‐2‐en‐1‐one (135950-61-7) → 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-(thien-2-yl)-3-pyridinecarboxylic acid,ethyl ester (137586-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

With copper diacetate; ammonium acetate; sodium ethanolate; In ethanol; acetic acid;

DOI:10.1021/jm00113a019

Reference yield:

2-Acetylthiophene (88-15-3,97511-16-5) → 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-(thien-2-yl)-3-pyridinecarboxylic acid,ethyl ester (137586-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: EtONa / ethanol / 16 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

With copper diacetate; ammonium acetate; sodium ethanolate; In ethanol; acetic acid;

DOI:10.1021/jm00113a019

upstream raw materials:

2-[1-(4-Fluoro-phenyl)-3-oxo-3-thiophen-2-yl-propyl]-4-methyl-3-oxo-pentanoic acid ethyl ester

(E)‐3‐(4‐fluorophenyl)‐1‐(thiophen‐2‐yl)prop‐2‐en‐1‐one

2-Acetylthiophene

4-fluorobenzaldehyde

Downstream raw materials:

(S)-4-[[[4-(4-Fluorophenyl)-2-(1-methylethyl)-6-(2-thienyl)-3-pyridinyl]ethynyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-thiophen-2-yl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

(S)-4-{[4-(4-Fluoro-phenyl)-2-isopropyl-6-thiophen-2-yl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-3-hydroxy-butyric acid methyl ester

3-(2,2-Dibromoethenyl)-4-(4-fluorophenyl)-2-(1-methylethyl)-6-(thien-2-yl)pyridine

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