N^α-[(tert-butyloxy)carbonyl]-N^β-[3(S)-[4-amino-6-[[1-(S)-(({4(S)-[({1(S)-[({2-[4'-({[3-(dimethylsulfonio)-1-propyl]amino}carbonyl)-2',4-bithiazol-2-yl]-1-ethyl}amino)carbonyl]-2(R)-hydroxy-1-propyl}amino)carbonyl]-3(S)-hydroxy-2(R)-pentyl}amino...

Base Information

• Chemical Name: N^α-[(tert-butyloxy)carbonyl]-N^β-[3(S)-[4-amino-6-[[1-(S)-(({4(S)-[({1(S)-[({2-[4'-({[3-(dimethylsulfonio)-1-propyl]amino}carbonyl)-2',4-bithiazol-2-yl]-1-ethyl}amino)carbonyl]-2(R)-hydroxy-1-propyl}amino)carbonyl]-3(S)-hydroxy-2(R)-pentyl}amino...
• CAS No.: 176752-46-8
• Molecular Formula: C₆₆H₈₄N₁₅O₁₂S₃
• Molecular Weight: 1375.68

Synonyms:N^α-[(tert-butyloxy)carbonyl]-N^β-[3(S)-[4-amino-6-[[1-(S)-(({4(S)-[({1(S)-[({2-[4'-({[3-(dimethylsulfonio)-1-propyl]amino}carbonyl)-2',4-bithiazol-2-yl]-1-ethyl}amino)carbonyl]-2(R)-hydroxy-1-propyl}amino)carbonyl]-3(S)-hydroxy-2(R)-pentyl}amino...

Chemical Property of N^α-[(tert-butyloxy)carbonyl]-N^β-[3(S)-[4-amino-6-[[1-(S)-(({4(S)-[({1(S)-[({2-[4'-({[3-(dimethylsulfonio)-1-propyl]amino}carbonyl)-2',4-bithiazol-2-yl]-1-ethyl}amino)carbonyl]-2(R)-hydroxy-1-propyl}amino)carbonyl]-3(S)-hydroxy-2(R)-pentyl}amino...

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Technology Process of N^α-[(tert-butyloxy)carbonyl]-N^β-[3(S)-[4-amino-6-[[1-(S)-(({4(S)-[({1(S)-[({2-[4'-({[3-(dimethylsulfonio)-1-propyl]amino}carbonyl)-2',4-bithiazol-2-yl]-1-ethyl}amino)carbonyl]-2(R)-hydroxy-1-propyl}amino)carbonyl]-3(S)-hydroxy-2(R)-pentyl}amino...

There total 8 articles about N^α-[(tert-butyloxy)carbonyl]-N^β-[3(S)-[4-amino-6-[[1-(S)-(({4(S)-[({1(S)-[({2-[4'-({[3-(dimethylsulfonio)-1-propyl]amino}carbonyl)-2',4-bithiazol-2-yl]-1-ethyl}amino)carbonyl]-2(R)-hydroxy-1-propyl}amino)carbonyl]-3(S)-hydroxy-2(R)-pentyl}amino... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

{3-[(2'-{2-[(2S,3R)-2-((2S,3S,4R)-4-Amino-3-hydroxy-2-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-ethyl}-[2,4']bithiazolyl-4-carbonyl)-amino]-propyl}-dimethyl-sulfonium + 6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester (176752-45-7) → Nα-[(tert-butyloxy)carbonyl]-Nβ-[3(S)-[4-amino-6-[[1-(S)-(({4(S)-[({1(S)-[({2-[4'-({[3-(dimethylsulfonio)-1-propyl]amino}carbonyl)-2',4-bithiazol-2-yl]-1-ethyl}amino)carbonyl]-2(R)-hydroxy-1-propyl}amino)carbonyl]-3(S)-hydroxy-2(R)-pentyl}amino... (176752-46-8)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 25 ℃; for 45h;

DOI:10.1016/0968-0896(95)00183-2

Reference yield:

(S)-2-Hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionic acid (176752-42-4) → Nα-[(tert-butyloxy)carbonyl]-Nβ-[3(S)-[4-amino-6-[[1-(S)-(({4(S)-[({1(S)-[({2-[4'-({[3-(dimethylsulfonio)-1-propyl]amino}carbonyl)-2',4-bithiazol-2-yl]-1-ethyl}amino)carbonyl]-2(R)-hydroxy-1-propyl}amino)carbonyl]-3(S)-hydroxy-2(R)-pentyl}amino... (176752-46-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / KI, K₂CO₃ / dimethylformamide / 20 h / 23 °C

2: 26 percent / Et₃N, BOPCl / CH₂Cl₂ / 96 h / 25 °C

3: 79 percent / H₂ / 10percent Pd/C / methanol / 0.5 h / 25 °C / 760 Torr

4: 89 percent / DCC, HOBt / dimethylformamide / 45 h / 25 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0968-0896(95)00183-2

Reference yield:

(S)-2-Hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionic acid benzyl ester (176752-43-5) → Nα-[(tert-butyloxy)carbonyl]-Nβ-[3(S)-[4-amino-6-[[1-(S)-(({4(S)-[({1(S)-[({2-[4'-({[3-(dimethylsulfonio)-1-propyl]amino}carbonyl)-2',4-bithiazol-2-yl]-1-ethyl}amino)carbonyl]-2(R)-hydroxy-1-propyl}amino)carbonyl]-3(S)-hydroxy-2(R)-pentyl}amino... (176752-46-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 26 percent / Et₃N, BOPCl / CH₂Cl₂ / 96 h / 25 °C

2: 79 percent / H₂ / 10percent Pd/C / methanol / 0.5 h / 25 °C / 760 Torr

3: 89 percent / DCC, HOBt / dimethylformamide / 45 h / 25 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0968-0896(95)00183-2

upstream raw materials:

6-Amino-2-[(S)-1-((S)-2-tert-butoxycarbonylamino-2-carbamoyl-ethylamino)-2-carbamoyl-ethyl]-5-methyl-pyrimidine-4-carboxylic acid (S)-1-carboxy-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester

(S)-2-Hydroxy-3-(1H-imidazol-4-yl)-propionic acid methyl ester

(S)-2-Hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionic acid

(S)-2-Hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propionic acid methyl ester

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