Technology Process of Benzylmethylenediphosphonic acid
There total 5 articles about Benzylmethylenediphosphonic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tetraethyl (2-phenylethylidene)bisphosphonate;
With
trimethylsilyl bromide;
at 20 ℃;
for 18h;
Inert atmosphere;
With
water;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1039/c2gc36800e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) NaH / 1.) toluene, 2.) toluene, 60 deg C, 16 h
2: 95 percent / 37percent aq. HCl / 15 h / Heating
With
hydrogenchloride; sodium hydride;
DOI:10.1021/jm00391a027
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: chloro(1,5-cyclooctadiene)rhodium(I) dimer / 1,4-dioxane; water / 6 h / 110 °C / Inert atmosphere; Schlenk technique
2.1: trimethylsilyl bromide / 18 h / 20 °C / Inert atmosphere
2.2: 4 h / 20 °C / Inert atmosphere
With
chloro(1,5-cyclooctadiene)rhodium(I) dimer; trimethylsilyl bromide;
In
1,4-dioxane; water;
DOI:10.1039/c2gc36800e
