1-(5-chloro-2-hydroxyphenyl)-1,4-dihydro-4-oxo-2-quinolineacetic acid ethyl ester

Base Information

Chemical Name:1-(5-chloro-2-hydroxyphenyl)-1,4-dihydro-4-oxo-2-quinolineacetic acid ethyl ester
CAS No.:80990-66-5
Molecular Formula:C₁₉H₁₆ClNO₄
Molecular Weight:357.793
Hs Code.:

Synonyms:1-(5-chloro-2-hydroxyphenyl)-1,4-dihydro-4-oxo-2-quinolineacetic acid ethyl ester

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Chemical Property of 1-(5-chloro-2-hydroxyphenyl)-1,4-dihydro-4-oxo-2-quinolineacetic acid ethyl ester

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Technology Process of 1-(5-chloro-2-hydroxyphenyl)-1,4-dihydro-4-oxo-2-quinolineacetic acid ethyl ester

There total 3 articles about 1-(5-chloro-2-hydroxyphenyl)-1,4-dihydro-4-oxo-2-quinolineacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 80990-65-4
<1-(5-chloro-2-hydroxyphenyl)-1,4-dihydro-4-oxo-2-quinolinyl)>propanedioic acid diethyl ester

: 80990-66-5
1-(5-chloro-2-hydroxyphenyl)-1,4-dihydro-4-oxo-2-quinolineacetic acid ethyl ester

Guidance literature:: In N,N,N,N,N,N-hexamethylphosphoric triamide; at 120 ℃; for 2.5h;

Reference yield:

: 54475-84-2
10-Chloro-5H-benzoxazole<3,2-a>quinolin-5-one

: 80990-66-5
1-(5-chloro-2-hydroxyphenyl)-1,4-dihydro-4-oxo-2-quinolineacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) HMPA, RT, 20 min, 2) RT, 3 h, 110 deg C, 1.5 h

2: 94 percent / hexamethylphosphoric acid triamide / 2.5 h / 120 °C

With sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide;