5'-O-[(2-cyano-1-pheylethoxy)carbonyl]-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 3'-(hydrogen butanedioate)

Base Information

• Chemical Name: 5'-O-[(2-cyano-1-pheylethoxy)carbonyl]-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 3'-(hydrogen butanedioate)
• CAS No.: 195881-31-3
• Molecular Formula: C₃₈H₄₁N₅O₁₆
• Molecular Weight: 823.767

Synonyms:5'-O-[(2-cyano-1-pheylethoxy)carbonyl]-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 3'-(hydrogen butanedioate)

Chemical Property of 5'-O-[(2-cyano-1-pheylethoxy)carbonyl]-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 3'-(hydrogen butanedioate)

Chemical Property:

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Safty Information:

• Pictogram(s):  
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Technology Process of 5'-O-[(2-cyano-1-pheylethoxy)carbonyl]-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 3'-(hydrogen butanedioate)

There total 6 articles about 5'-O-[(2-cyano-1-pheylethoxy)carbonyl]-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 3'-(hydrogen butanedioate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

succinic acid anhydride (108-30-5) + 5'-O-[(2-cyano-1-pheylethoxy)carbonyl]-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine (195881-22-2) → 5'-O-[(2-cyano-1-pheylethoxy)carbonyl]-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 3'-(hydrogen butanedioate) (195881-31-3)

Guidance literature:

With 1-methyl-1H-imidazole; In dichloromethane;

DOI:10.1080/07328319708002955

Reference yield:

N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytosine (155834-52-9) → 5'-O-[(2-cyano-1-pheylethoxy)carbonyl]-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 3'-(hydrogen butanedioate) (195881-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / pyridine / CH₂Cl₂ / -60 - -20 °C

2: 94 percent / 1-methyl-1H-imidazole / CH₂Cl₂ / 17 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; In dichloromethane;

DOI:10.1002/hlca.200390206

Reference yield:

2-cyano-1-phenylethyl carbonochloridate (195881-17-5) → 5'-O-[(2-cyano-1-pheylethoxy)carbonyl]-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 3'-(hydrogen butanedioate) (195881-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / pyridine / CH₂Cl₂ / -60 - -20 °C

2: 94 percent / 1-methyl-1H-imidazole / CH₂Cl₂ / 17 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; In dichloromethane;

DOI:10.1002/hlca.200390206

upstream raw materials:

succinic acid anhydride

5'-O-[(2-cyano-1-pheylethoxy)carbonyl]-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine

4-methoxy-2,6-dihydropyran

N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytosine

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