2-[(S)-1-Cbz-amino-2-methylpropyl]-4-methoxyoxazole-4-carbonyl-L-Val-OMe

Base Information

Chemical Name:2-[(S)-1-Cbz-amino-2-methylpropyl]-4-methoxyoxazole-4-carbonyl-L-Val-OMe
CAS No.:737008-99-0
Molecular Formula:C₂₃H₃₃N₃O₇
Molecular Weight:463.531
Hs Code.:

Synonyms:2-[(S)-1-Cbz-amino-2-methylpropyl]-4-methoxyoxazole-4-carbonyl-L-Val-OMe

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Chemical Property of 2-[(S)-1-Cbz-amino-2-methylpropyl]-4-methoxyoxazole-4-carbonyl-L-Val-OMe

Chemical Property:

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Technology Process of 2-[(S)-1-Cbz-amino-2-methylpropyl]-4-methoxyoxazole-4-carbonyl-L-Val-OMe

There total 4 articles about 2-[(S)-1-Cbz-amino-2-methylpropyl]-4-methoxyoxazole-4-carbonyl-L-Val-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 737008-98-9
(S)-2-[2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-bromo-2-methoxy-propionylamino]-3-methyl-butyric acid methyl ester

: 737008-99-0
2-[(S)-1-Cbz-amino-2-methylpropyl]-4-methoxyoxazole-4-carbonyl-L-Val-OMe

Guidance literature:: With caesium carbonate; In 1,4-dioxane; at 60 ℃; for 6h;
DOI:10.1246/cl.2004.664

Reference yield:

: Cbz-L-Val-L-Ser-L-Val-OMe

: 737008-99-0
2-[(S)-1-Cbz-amino-2-methylpropyl]-4-methoxyoxazole-4-carbonyl-L-Val-OMe

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CHCl₃ / 1 h / 0 °C

2: 1.39 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / CHCl₃ / 1.5 h / 0 - 20 °C

3: 93 percent / N-bromosuccinimide / tetrahydrofuran / 0.5 h / 0 °C

4: 60 percent / Cs₂CO₃ / dioxane / 60 °C

With N-Bromosuccinimide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; 1,4-dioxane; chloroform;
DOI:10.1246/bcsj.78.1492

Reference yield:

: 737008-97-8
Cbz-L-Val-ΔAla-L-Val-OMe

: 737008-99-0
2-[(S)-1-Cbz-amino-2-methylpropyl]-4-methoxyoxazole-4-carbonyl-L-Val-OMe

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / N-bromosuccinimide / tetrahydrofuran / 0.5 h / 0 °C

2: 60 percent / Cs₂CO₃ / dioxane / 60 °C

With N-Bromosuccinimide; caesium carbonate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1246/bcsj.78.1492