methyl (S,S,S)-2-{1-[2-(1-{2-[1-Cbz-amino-2-methylpropyl]oxazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonylamino]-2-methylpropyl}-5-methyloxazole-4-carboxylate

Base Information

Chemical Name:methyl (S,S,S)-2-{1-[2-(1-{2-[1-Cbz-amino-2-methylpropyl]oxazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonylamino]-2-methylpropyl}-5-methyloxazole-4-carboxylate
CAS No.:737009-10-8
Molecular Formula:C₃₄H₄₂N₆O₈S
Molecular Weight:694.809
Hs Code.:

methyl (S,S,S)-2-{1-[2-(1-{2-[1-Cbz-amino-2-methylpropyl]oxazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonylamino]-2-methylpropyl}-5-methyloxazole-4-carboxylate

Synonyms:methyl (S,S,S)-2-{1-[2-(1-{2-[1-Cbz-amino-2-methylpropyl]oxazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonylamino]-2-methylpropyl}-5-methyloxazole-4-carboxylate

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Chemical Property of methyl (S,S,S)-2-{1-[2-(1-{2-[1-Cbz-amino-2-methylpropyl]oxazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonylamino]-2-methylpropyl}-5-methyloxazole-4-carboxylate

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Technology Process of methyl (S,S,S)-2-{1-[2-(1-{2-[1-Cbz-amino-2-methylpropyl]oxazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonylamino]-2-methylpropyl}-5-methyloxazole-4-carboxylate

There total 21 articles about methyl (S,S,S)-2-{1-[2-(1-{2-[1-Cbz-amino-2-methylpropyl]oxazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonylamino]-2-methylpropyl}-5-methyloxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2-{(S)-1-[3-((S)-2-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-3-methyl-thiobutyrylamino)-2-oxo-propionylamino]-2-methyl-propyl}-5-methyl-oxazole-4-carboxylic acid methyl ester

: 737009-10-8
methyl (S,S,S)-2-{1-[2-(1-{2-[1-Cbz-amino-2-methylpropyl]oxazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonylamino]-2-methylpropyl}-5-methyloxazole-4-carboxylate

Guidance literature:: 2-{(S)-1-[3-((S)-2-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-3-methyl-thiobutyrylamino)-2-oxo-propionylamino]-2-methyl-propyl}-5-methyl-oxazole-4-carboxylic acid methyl ester; With pyridine; trifluoroacetic anhydride; at 0 ℃; for 1h;

With ammonium hydroxide; at 0 ℃;
DOI:10.1246/cl.2004.664

Reference yield: 90.0%

: 737008-95-6
methyl (S)-2-[1-(3-bromo-2-oxopropanoyl)amino-2-methylpropyl]-5-methyloxazole-4-carboxylate

: 737008-94-5
N-{2-[(S)-1-Cbz-amino-2-methylpropyl]oxazol-4-ylcarbonyl}-L-Val-(S)NH₂

: 737009-10-8
methyl (S,S,S)-2-{1-[2-(1-{2-[1-Cbz-amino-2-methylpropyl]oxazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonylamino]-2-methylpropyl}-5-methyloxazole-4-carboxylate

Guidance literature:: With potassium hydrogencarbonate; In 1,2-dimethoxyethane; at 0 - 50 ℃;
DOI:10.1246/bcsj.78.1492

Reference yield:

: 737008-99-0
2-[(S)-1-Cbz-amino-2-methylpropyl]-4-methoxyoxazole-4-carbonyl-L-Val-OMe

: 737009-10-8
methyl (S,S,S)-2-{1-[2-(1-{2-[1-Cbz-amino-2-methylpropyl]oxazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonylamino]-2-methylpropyl}-5-methyloxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / camphorsulfonic acid / toluene / 48 h / 70 °C

2: LiOH / tetrahydrofuran; H₂O / 1.5 h / 0 - 20 °C

3: 81 percent / Et₃N; ClCOOEt; NH₃ / tetrahydrofuran / 0.08 h / 0 °C

4: 92 percent / Lawesson's reagent / tetrahydrofuran / 20 °C

5: 90 percent / KHCO₃ / 1,2-dimethoxy-ethane / 0 - 50 °C

With Lawessons reagent; lithium hydroxide; camphor-10-sulfonic acid; ammonia; chloroformic acid ethyl ester; potassium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;
DOI:10.1246/bcsj.78.1492