C₁₂H₁₁FN₂

Base Information

Chemical Name:C₁₂H₁₁FN₂
CAS No.:1428447-04-4
Molecular Formula:C₁₂H₁₁FN₂
Molecular Weight:202.231
Hs Code.:

C<sub>12</sub>H<sub>11</sub>FN<sub>2</sub>

Synonyms:C₁₂H₁₁FN₂

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Chemical Property of C₁₂H₁₁FN₂

Chemical Property:

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Technology Process of C₁₂H₁₁FN₂

There total 4 articles about C₁₂H₁₁FN₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1326316-10-2
3-trifluoromethanesulfonyloxy-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole

: 1765-93-1
4-fluoroboronic acid

: 1428447-04-4
C₁₂H₁₁FN₂

Guidance literature:: With Aliquat 336; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,2-dimethoxyethane; water; at 130 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;
DOI:10.1248/cpb.c12-00725

Reference yield:

: 1326316-18-0
4-allyloxy-1-trityl-1H-pyrazole

: 1428447-04-4
C₁₂H₁₁FN₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1 h / 190 °C / Microwave irradiation

2.1: triethylamine / dichloromethane / 0.5 h / -20 °C

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 0 - 20 °C

3.2: 20 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 24 h / 20 °C

5.1: hydrogenchloride / water; ethanol / 18 h / 80 °C

6.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium carbonate; tricyclohexylphosphine; Aliquat 336 / water; 1,2-dimethoxyethane / 0.5 h / 130 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; Aliquat 336; sodium carbonate; triethylamine; 9-bora-bicyclo[3.3.1]nonane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1.1: |Claisen Rearrangement / 6.1: |Suzuki-Miyaura Coupling;
DOI:10.1248/cpb.c12-00725

Reference yield:

: 1326316-03-3
3-allyl-4-trifluoromethanesulfonyloxy-2-trityl-2H-pyrazole

: 1428447-04-4
C₁₂H₁₁FN₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 0 - 20 °C

1.2: 20 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 24 h / 20 °C

3.1: hydrogenchloride / water; ethanol / 18 h / 80 °C

4.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium carbonate; tricyclohexylphosphine; Aliquat 336 / water; 1,2-dimethoxyethane / 0.5 h / 130 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; Aliquat 336; sodium carbonate; triethylamine; 9-bora-bicyclo[3.3.1]nonane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1248/cpb.c12-00725