1326316-18-0Relevant articles and documents
Cui-catalyzed coupling reactions of 4-iodopyrazoles and alcohols: Application toward withasomnine and Homologs
Harusawa, Shinya,Hayama, Noboru,Kubo, Yumika,Kuroiwa, Nao,Nakamizu, Ayaka,Nishikawa, Kohei,Ono, Jun,Takagaki, Toshiki,Tatsui, Yuya,Usami, Yoshihide,Yoneyama, Hiroki
, (2021)
The direct 4-alkoxylation of 4-iodo-1H-pyrazoles with alcohols was achieved by a CuIcatalyzed coupling protocol. The optimal reaction conditions employed excess alcohol and potassium t-butoxide (2 equiv) in the presence of CuI (20 mol%) and 3,4,7,8-tetramethyl-1,10-phenanthroline (20 mol%) at 130 °C for 1 h under microwave irradiation. The present method was efficiently applied to the synthesis of withasomnine and its six- and seven-membered cyclic homologs.