1-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11-yl)-3-ethylurea

Base Information

Chemical Name:1-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11-yl)-3-ethylurea
CAS No.:1589554-78-8
Molecular Formula:C₁₉H₂₅N₃O₄
Molecular Weight:359.425
Hs Code.:

Synonyms:1-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11-yl)-3-ethylurea

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Chemical Property of 1-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11-yl)-3-ethylurea

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Technology Process of 1-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11-yl)-3-ethylurea

There total 3 articles about 1-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11-yl)-3-ethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1589556-08-0
(3R,11R,E)-11-amino-3-phenyl-1-oxa-4-azacyclododec-8 ene-5,12-dione trifluoroacetate

: 109-90-0
ethyl isocyanate

: 1589554-78-8
1-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11-yl)-3-ethylurea

Guidance literature:: With triethylamine; In tetrahydrofuran; for 185h; Inert atmosphere;

Reference yield:

: 1589558-50-8
tert-butyl ((4R,8S)-5-oxo-8-(pent-4-enamido)-8-phenyloct-1-en-4-yl)carbamate

: 1589554-78-8
1-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11-yl)-3-ethylurea

Guidance literature:: Multi-step reaction with 3 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 3-carboxy-2-mercaptopyridine / dichloromethane / 3 h / 20 °C

2: triethylsilane / dichloromethane / 4 h / 20 °C

3: triethylamine / tetrahydrofuran / 185 h / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; triethylsilane; 3-carboxy-2-mercaptopyridine; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1589556-07-9
tert-butyl ((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11-yl)carbamate

: 1589554-78-8
1-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11-yl)-3-ethylurea

Guidance literature:: Multi-step reaction with 2 steps

1: triethylsilane / dichloromethane / 4 h / 20 °C

2: triethylamine / tetrahydrofuran / 185 h / Inert atmosphere

With triethylsilane; triethylamine; In tetrahydrofuran; dichloromethane;