1-(5-chloro-4'-ethyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylic acid

Base Information

Chemical Name:1-(5-chloro-4'-ethyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylic acid
CAS No.:1168120-49-7
Molecular Formula:C₂₁H₂₀ClF₃O₃
Molecular Weight:412.836
Hs Code.:

Synonyms:1-(5-chloro-4'-ethyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylic acid

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Chemical Property of 1-(5-chloro-4'-ethyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylic acid

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Technology Process of 1-(5-chloro-4'-ethyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylic acid

There total 5 articles about 1-(5-chloro-4'-ethyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1168134-73-3
ethyl 1-(5-chloro-4'-ethyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylate

: 1168120-49-7
1-(5-chloro-4'-ethyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylic acid

Guidance literature:: ethyl 1-(5-chloro-4'-ethyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylate; With methanol; water; lithium hydroxide; In tetrahydrofuran; at 20 - 25 ℃; for 3h;

With hydrogenchloride; water;

Reference yield:

: 193357-36-7
3-chloro-4-hydroxyphenylacetic acid ethyl ester

: 1168120-49-7
1-(5-chloro-4'-ethyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / chloroform / 1 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane / 100 °C

4: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 3 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; bromine; potassium carbonate; cesium fluoride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1168134-12-0
ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)acetate

: 1168120-49-7
1-(5-chloro-4'-ethyl-6-(2,2,2-trifluoroethoxy)biphenyl-3-yl)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane / 100 °C

2: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 3 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; cesium fluoride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane;