193357-36-7

Upstream product

• 33697-81-3 (3-chloro-4-hydroxy-phenyl)-acetic acid 
• 75-03-6 ethyl iodide 
• 17138-28-2 (4-hydroxy-phenyl)-acetic acid ethyl ester 
• 64-17-5 ethanol 
• 39923-59-6 ethyl 3-chloro-4-methoxyphenylacetate 

Downstream Products

• 494865-21-3 ethyl {4-[3,3-bis-(4-bromo-phenyl)-allyloxy]-3-chloro-phenyl}-acetate 
• 1207542-68-4 C₁₇H₁₃Cl₂NO₃ 
• 1207543-35-8 C₁₆H₁₃Cl₃O₃ 
• 1207543-43-8 C₁₈H₁₆ClNO₃ 
• 1168134-12-0 ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)acetate 
• 1168133-68-3 ethyl 2-(3-bromo-5-chloro-4-hydroxyphenyl)acetate 
• 1168133-69-4 ethyl 2-(3-bromo-5-chloro-4-(cyclopropylmethoxy)phenyl)acetate 
• 1168111-82-7 2-(3-(benzo[c][1,2,5]thiadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid 
• 1168134-93-7 ethyl 2-(3-(benzo[c][1,2,5]thiadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate 
• 1168111-72-5 2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid 
• 1168134-92-6 ethyl 2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate 
• 1168135-11-2 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid 
• 1168134-91-5 ethyl 2-(3-(benzo[d]thiazol-6-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate 
• 1168134-90-4 ethyl 2-(3-bromo-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate 

Relevant academic research and scientific papers

TETRASUBSTITUTED BENZENES

Provided herein are tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease.

TETRASUBSTITUTED BENZENES FOR TREATMENT OF EARLY ONSET ALZHEIMER'S DISEASE

Provided are compositions and methods for treating early onset familial Alzheimer's Disease. The compositions and methods can be used for improving one or more aspects of cognitive function in a patient suffering from early onset familial Alzheimer's Dise

The SAR analysis of TRPV1 agonists with the α-methylated B-region

A series of TRPV1 agonists with amide, reverse amide, and thiourea groups in the B-region and their corresponding α-methylated analogues were investigated. Whereas the α-methylation of the amide B-region enhanced the binding affinities and potencies as agonists, that of the reverse amide and thiourea led to a reduction in receptor affinity. The analysis indicated that proper hydrogen bonding as well as steric effects in the B-region are critical for receptor binding.

TETRASUBSTITUTED BENZENES

Tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease, are described.

Identification and synthesis of a novel selective partial PPARδ agonist with full efficacy on lipid metabolism in vitro and in vivo

The aim was to identify a novel selective PPARδ agonist with full efficacy on free fatty acid (FFA) oxidation in vitro and plasma lipid correction in vivo. Using the triple PPARα,γ,δ agonist 1 as the structural starting point, we wanted to investigate the

Non-nucleoside reverse transcriptase inhibitors

The present invention provides for compounds useful for treating an HIV-1 infection, or preventing an HIV-1 infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1-R4 and Ar are as herein defined. Also disclosed in t

Novel compounds, their preparation and use

Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be u

An improved method for preparation of carboxylic esters using CsF- celite/alkyl halide/CH3CN combination

A new method for efficient and chemoselective esterification of carboxylic acids in CsF-Celite/alkyl halide/CH3CN reaction system is described.