Technology Process of 3'-Fluoro-3'-deoxycytidine
There total 20 articles about 3'-Fluoro-3'-deoxycytidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 93 percent / pyridine / 28 h / Ambient temperature
2: 33.6 percent / dibenzo-18-crown-6 / dimethylsulfoxide / 7 h / 205 - 210 °C
3: 97 percent / H2 / 10percent Pd/C / ethanol / 72 h / Ambient temperature
4: 94 percent / pyridine / 12 h / Ambient temperature
5: 94 percent / concd. H2SO4, AcOH / 20 h / Ambient temperature
6: 75 percent / SnCl4 / 1,2-dichloro-ethane / 1 h / Heating
7: 81 percent / ammonia / methanol / 48 h
With
pyridine; dibenzo-18-crown-6; sulfuric acid; ammonia; hydrogen; tin(IV) chloride; acetic acid;
palladium on activated charcoal;
In
methanol; ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/jm00111a040
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 45 percent / KHF2, NaF / ethane-1,2-diol / 4 h / Heating
2: 93 percent / pyridine / 28 h / Ambient temperature
3: 33.6 percent / dibenzo-18-crown-6 / dimethylsulfoxide / 7 h / 205 - 210 °C
4: 97 percent / H2 / 10percent Pd/C / ethanol / 72 h / Ambient temperature
5: 94 percent / pyridine / 12 h / Ambient temperature
6: 94 percent / concd. H2SO4, AcOH / 20 h / Ambient temperature
7: 75 percent / SnCl4 / 1,2-dichloro-ethane / 1 h / Heating
8: 81 percent / ammonia / methanol / 48 h
With
pyridine; dibenzo-18-crown-6; potassium hydrogen bifluoride; sulfuric acid; ammonia; hydrogen; tin(IV) chloride; sodium fluoride; acetic acid;
palladium on activated charcoal;
In
methanol; ethanol; ethylene glycol; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/jm00111a040