14980-09-7Relevant articles and documents
Ring opening of sugar-derived epoxides by TBAF/KHF2: An attractive alternative for the introduction of fluorine into the carbohydrate scaffold
Yan, Nan,Lei, Zhi-Wei,Su, Jia-Kun,Liao, Wei-Lin,Hu, Xiang-Guo
, p. 467 - 470 (2017)
A stable and commercially available reagent mixture, composed of tetrabutylammonium bifluoride/potassium bifluoride (TBAF/KHF2), was found to be effective for the nucleophilic ring opening reactions of sugar-derived epoxides with fluoride. Diff
Fluoroglycolactone synthesis method
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, (2022/03/27)
The invention discloses a synthesis method of fluoro sugar lactone. According to the method, D-xylose is taken as a starting raw material, hydroxyl is protected to synthesize a lactonide compound intermediate, and then the fluoroglycolactone is obtained through the steps of stereo conversion of sugar cyclic alcohol, benzyl addition, methyl glycoside removal, hydroxyl oxidation and the like. The raw materials adopted by the synthesis method are simple, cheap and easy to obtain, each synthesis step is mild in condition, the treatment process is simple, the yield is relatively high, and new raw materials and synthesis ways are provided for design of fluorine-containing bioactive molecules.
NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
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, (2010/05/13)
The invention provides unsaturated phosphonates of Formula I or a tautomer or pharmaceutically accepatble salt thereof, as described herein, as well as pharmaceutical compositions comprising the compounds, and therapeutic methods comprising administering the compounds. The compounds have anti-viral properties and are useful for treating viral infections (e.g. HCV) in animals (e.g. humans).
Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases
Mikhailopulo,Poopeiko,Pricota,Sivets,Kvasyuk,Balzarini,De Clercq
, p. 2195 - 2202 (2007/10/02)
A series of 3'-deoxy-3'-fluoro- and 2'-azido-2',3'-dideoxy-3'-fluoro-D-ribofuranosides of natural heterocyclic bases have been synthesized with the use of universal carbohydrate precursors, viz., 1-O-acetyl-2,5-di-O-benzoyl-3-deoxy-3-fluoro-D-ribofuranose