3-(1-methyl-1H-pyrazol-5-yl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole

Base Information

Chemical Name:3-(1-methyl-1H-pyrazol-5-yl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole
CAS No.:1356997-73-3
Molecular Formula:C₁₄H₁₀F₃N₃O
Molecular Weight:293.248
Hs Code.:

Synonyms:3-(1-methyl-1H-pyrazol-5-yl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole

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Chemical Property of 3-(1-methyl-1H-pyrazol-5-yl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole

Chemical Property:

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Technology Process of 3-(1-methyl-1H-pyrazol-5-yl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole

There total 4 articles about 3-(1-methyl-1H-pyrazol-5-yl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356997-75-5
N-hydroxy-1-(1-methyl-1H-pyrazol-5-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-imine

: 1356997-73-3
3-(1-methyl-1H-pyrazol-5-yl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole

Guidance literature:: With hydrogenchloride; acetic acid; In water; at 20 ℃; for 0.5h; Reflux;

Reference yield:

: 16034-46-1
1-methyl-1H-pyrazole-5-carboxylic acid

: 1356997-73-3
3-(1-methyl-1H-pyrazol-5-yl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: methylmagnesium bromide / tetrahydrofuran / 2 h / Cooling with ice

2.2: 3.5 h / -78 °C / Cooling with ice

3.1: sodium carbonate; hydroxylamine hydrochloride / methanol; water / 20 °C

4.1: acetic acid; hydrogenchloride / water / 0.5 h / 20 °C / Reflux

With hydrogenchloride; methylmagnesium bromide; hydroxylamine hydrochloride; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1339452-16-2
N-methoxy-N-methyl-2-methyl-2H-pyrazole-3-carboxamide

: 1356997-73-3
3-(1-methyl-1H-pyrazol-5-yl)-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: methylmagnesium bromide / tetrahydrofuran / 2 h / Cooling with ice

1.2: 3.5 h / -78 °C / Cooling with ice

2.1: sodium carbonate; hydroxylamine hydrochloride / methanol; water / 20 °C

3.1: acetic acid; hydrogenchloride / water / 0.5 h / 20 °C / Reflux

With hydrogenchloride; methylmagnesium bromide; hydroxylamine hydrochloride; sodium carbonate; acetic acid; In tetrahydrofuran; methanol; water;