N-hydroxy-1-(1-methyl-1H-pyrazol-5-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-imine

Base Information

Chemical Name:N-hydroxy-1-(1-methyl-1H-pyrazol-5-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-imine
CAS No.:1356997-75-5
Molecular Formula:C₁₄H₁₀F₃N₃O
Molecular Weight:293.248
Hs Code.:

Synonyms:N-hydroxy-1-(1-methyl-1H-pyrazol-5-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-imine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-hydroxy-1-(1-methyl-1H-pyrazol-5-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-imine

Chemical Property:

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Technology Process of N-hydroxy-1-(1-methyl-1H-pyrazol-5-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-imine

There total 3 articles about N-hydroxy-1-(1-methyl-1H-pyrazol-5-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356997-74-4
1-(1-methyl-1H-pyrazol-5-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one

: 1356997-75-5
N-hydroxy-1-(1-methyl-1H-pyrazol-5-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-imine

Guidance literature:: With hydroxylamine hydrochloride; sodium carbonate; In methanol; water; at 20 ℃;

Reference yield:

: 16034-46-1
1-methyl-1H-pyrazole-5-carboxylic acid

: 1356997-75-5
N-hydroxy-1-(1-methyl-1H-pyrazol-5-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-imine

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: methylmagnesium bromide / tetrahydrofuran / 2 h / Cooling with ice

2.2: 3.5 h / -78 °C / Cooling with ice

3.1: sodium carbonate; hydroxylamine hydrochloride / methanol; water / 20 °C

With methylmagnesium bromide; hydroxylamine hydrochloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1339452-16-2
N-methoxy-N-methyl-2-methyl-2H-pyrazole-3-carboxamide

: 1356997-75-5
N-hydroxy-1-(1-methyl-1H-pyrazol-5-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-imine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methylmagnesium bromide / tetrahydrofuran / 2 h / Cooling with ice

1.2: 3.5 h / -78 °C / Cooling with ice

2.1: sodium carbonate; hydroxylamine hydrochloride / methanol; water / 20 °C

With methylmagnesium bromide; hydroxylamine hydrochloride; sodium carbonate; In tetrahydrofuran; methanol; water;