4-Sulfamoylthiophene-3-carboxylic acid

Base Information

Chemical Name:4-Sulfamoylthiophene-3-carboxylic acid
CAS No.:59337-86-9
Molecular Formula:C5H5NO4S2
Molecular Weight:207.2275
Hs Code.:
DSSTox Substance ID:DTXSID00208084
Nikkaji Number:J762.274K
Wikidata:Q83082175

Synonyms:4-Sulfamoylthiophene-3-carboxylic acid;4-(Aminosulfonyl)-3-thiophenecarboxylic acid;3-Thiophenecarboxylic acid, 4-(aminosulfonyl)-;59337-86-9;SCHEMBL10835741;DTXSID00208084;VAHHPJSRCPYDLP-UHFFFAOYSA-N;4-aminosulfonylthiophene-3-carboxylic acid;LS-152981

Suppliers and Price of 4-Sulfamoylthiophene-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 4-Sulfamoylthiophene-3-carboxylic acid

Chemical Property:

Vapor Pressure:3.52E-10mmHg at 25°C
Boiling Point:484°Cat760mmHg
Flash Point:246.5°C
Density:1.721g/cm³
XLogP3:-0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:206.96599999
Heavy Atom Count:12
Complexity:280

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=CS1)S(=O)(=O)N)C(=O)O

Technology Process of 4-Sulfamoylthiophene-3-carboxylic acid

There total 2 articles about 4-Sulfamoylthiophene-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 59337-78-9
4-(aminosulfonyl)-3-thiophenecarboxylic acid methyl ester

: 59337-86-9
4-(aminosulfonyl)-3-thiophenecarboxylic acid

Guidance literature:: With sodium hydroxide; for 2h; Heating;
DOI:10.1002/ardp.19963290503

Reference yield:

: 59337-85-8
4-chlorosulfonylthiophene-3-carboxylic acid methyl ester

: 59337-86-9
4-(aminosulfonyl)-3-thiophenecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / NH₃ / 4 h / 0 °C

2: 68 percent / 1 N aq. NaOH / 2 h / Heating

With sodium hydroxide; ammonia;
DOI:10.1002/ardp.19963290503

Reference yield:

: 59337-86-9
4-(aminosulfonyl)-3-thiophenecarboxylic acid

: (1,1-Dioxo-1H-1λ⁶-thieno[3,4-d]isothiazol-3-yl)-[3-(3-piperidin-1-ylmethyl-phenoxy)-propyl]-amine; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / SOCl₂ / 4 h / Heating

2: 32 percent / tetrahydrofuran / 0.25 h

3: 47 percent / POCl₃ / 0.5 h / Heating

4: 1.) POCl₃, 2.) NaBH₄ / 1) heating; 2) 1,2-dimethoxyethane, room temperature, 1 h

With sodium tetrahydroborate; thionyl chloride; trichlorophosphate; In tetrahydrofuran;