59337-78-9

Upstream product

• 59337-85-8 4-chlorosulfonylthiophene-3-carboxylic acid methyl ester 
• 59337-79-0 thieno(3,4-d)-1,2-thiazol-3(2H)-one 1,1-dioxide 
• 67-56-1 methanol 

Downstream Products

• 114033-52-2 4-(aminosulfonyl)-N-<3-(3-formylphenoxy)propyl>-3-thiophenecarboxamide 
• 59337-86-9 4-(aminosulfonyl)-3-thiophenecarboxylic acid 
• 59337-94-9 2,3-dihydro-3-oxo-thieno<2,3-d>isothiazole-1,1-dioxide 

Relevant academic research and scientific papers

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

SEMICONDUCTING POLYMERS AND TERNARY BLENDS THEREOF

Semiconducting photovoltaic polymers and compositions are disclosed. The polymers and compositions exhibit increased power conversion efficiency in solar cells and other applications.

AMIDINO COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS

The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

Synthesis and anti-inflammatory evaluation of new sulfamoylheterocarboxylic derivatives

A series of new sulfamoylthiophene and sulfamoylpyrazole carboxylic acid derivatives was synthesized. Some of these compounds show interesting analgesic properties and significant nonsteroidal anti-inflammatory activities in several models of inflammation.

Aromatization of Dihydrothiophenes. Thiophenesaccharin: A Sweet Surprise

Sulfuryl chloride has been shown to be highly effective in the dehydrogenation of 3,4-disubstituted-2,5-dihydrothiophenes and 2,3-disubstituted-4,5-dihydrothiophenes, in which the 3,4 and 2,3 substitutents are part of a β-keto carbonyl functionality or it