methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate

Base Information

Chemical Name:methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate
CAS No.:1265400-51-8
Molecular Formula:C₂₇H₃₁N₃O₂
Molecular Weight:429.562
Hs Code.:

Synonyms:methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate

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Chemical Property of methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate

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Technology Process of methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate

There total 7 articles about methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1265400-26-7
methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate

: 100-39-0
benzyl bromide

: 1265400-51-8
methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate

Guidance literature:: methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 ℃; for 0.25h;

benzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 - 20 ℃; for 3h;

Reference yield:

: 162498-52-4
(2,4-dichloro-6-methylpyrimidin-5-yl)acetic acid methyl ester

: 1265400-51-8
methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

2.1: tetrahydrofuran / 1 h / 110 °C / Sealed tube; Microwave irradiation

3.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -15 °C

3.2: 3 h / -15 - 20 °C

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 10420-33-4
dimethyl 2-acetylsuccinate

: 1265400-51-8
methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / methanol / 18 h / Reflux

1.2: 0 °C

2.1: water; chloroacetic acid / 24 h / Reflux

3.1: thionyl chloride / 12 h / 0 °C / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 115 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

6.1: tetrahydrofuran / 1 h / 110 °C / Sealed tube; Microwave irradiation

7.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -15 °C

7.2: 3 h / -15 - 20 °C

With thionyl chloride; water; sodium methylate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; chloroacetic acid; lithium hexamethyldisilazane; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;