4-[[(4-chloro-butyl)-methyl-amino]-(5-nitro-furan-2-ylmethoxy)-phosphoryloxy]-benzoic acid allyl ester

Base Information

Chemical Name:4-[[(4-chloro-butyl)-methyl-amino]-(5-nitro-furan-2-ylmethoxy)-phosphoryloxy]-benzoic acid allyl ester
CAS No.:365431-83-0
Molecular Formula:C₂₀H₂₄ClN₂O₈P
Molecular Weight:486.846
Hs Code.:

Synonyms:4-[[(4-chloro-butyl)-methyl-amino]-(5-nitro-furan-2-ylmethoxy)-phosphoryloxy]-benzoic acid allyl ester

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Chemical Property of 4-[[(4-chloro-butyl)-methyl-amino]-(5-nitro-furan-2-ylmethoxy)-phosphoryloxy]-benzoic acid allyl ester

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Technology Process of 4-[[(4-chloro-butyl)-methyl-amino]-(5-nitro-furan-2-ylmethoxy)-phosphoryloxy]-benzoic acid allyl ester

There total 5 articles about 4-[[(4-chloro-butyl)-methyl-amino]-(5-nitro-furan-2-ylmethoxy)-phosphoryloxy]-benzoic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 365432-15-1
N-methyl-N-(4-chlorobutyl) O-4-carboxyallylphenyl phosphoramidic chloride

: 2493-04-1
(5-nitrofuran-2-yl)methanol

: 365431-83-0
4-[[(4-chloro-butyl)-methyl-amino]-(5-nitro-furan-2-ylmethoxy)-phosphoryloxy]-benzoic acid allyl ester

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -40 ℃; for 5.5h;
DOI:10.1021/jm060142p

Reference yield:

: 18982-18-8
allyl 4-hydroxybenzoate

: 365431-83-0
4-[[(4-chloro-butyl)-methyl-amino]-(5-nitro-furan-2-ylmethoxy)-phosphoryloxy]-benzoic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / -15 - -5 °C

2: 52 percent / LiHMDS / tetrahydrofuran / 5.5 h / -40 °C

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm060142p

Reference yield:

: N-methyl-N-(4-chloro-n-butyl)amine hydrochloride

: 365431-83-0
4-[[(4-chloro-butyl)-methyl-amino]-(5-nitro-furan-2-ylmethoxy)-phosphoryloxy]-benzoic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / POCl₃; Et₃N / CH₂Cl₂ / 20 °C

2: 63 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / -15 - -5 °C

3: 52 percent / LiHMDS / tetrahydrofuran / 5.5 h / -40 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm060142p