N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-carboxy)phenyl phosphoramidate

Base Information

Chemical Name:N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-carboxy)phenyl phosphoramidate
CAS No.:365431-93-2
Molecular Formula:C₁₇H₂₀ClN₂O₈P
Molecular Weight:446.781
Hs Code.:

Synonyms:N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-carboxy)phenyl phosphoramidate

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Chemical Property of N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-carboxy)phenyl phosphoramidate

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Technology Process of N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-carboxy)phenyl phosphoramidate

There total 6 articles about N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-carboxy)phenyl phosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 365431-83-0
4-[[(4-chloro-butyl)-methyl-amino]-(5-nitro-furan-2-ylmethoxy)-phosphoryloxy]-benzoic acid allyl ester

: 365431-93-2
N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-carboxy)phenyl phosphoramidate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium 4-methylbenzenesulfinate; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/jm060142p

Reference yield:

: 365432-15-1
N-methyl-N-(4-chlorobutyl) O-4-carboxyallylphenyl phosphoramidic chloride

: 365431-93-2
N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-carboxy)phenyl phosphoramidate

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / LiHMDS / tetrahydrofuran / 5.5 h / -40 °C

2: 78 percent / aq. sodium p-toluenesulfinate; Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium 4-methylbenzenesulfinate; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jm060142p

Reference yield:

: 18982-18-8
allyl 4-hydroxybenzoate

: 365431-93-2
N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-carboxy)phenyl phosphoramidate

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / -15 - -5 °C

2: 52 percent / LiHMDS / tetrahydrofuran / 5.5 h / -40 °C

3: 78 percent / aq. sodium p-toluenesulfinate; Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium 4-methylbenzenesulfinate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm060142p