(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(piperazin-1-yl)methanone trifluoroacetate

Base Information

Chemical Name:(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(piperazin-1-yl)methanone trifluoroacetate
CAS No.:1355052-37-7
Molecular Formula:C₂HF₃O₂*C₂₂H₂₀FN₃O₂
Molecular Weight:491.442
Hs Code.:

Synonyms:(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(piperazin-1-yl)methanone trifluoroacetate

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Chemical Property of (6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(piperazin-1-yl)methanone trifluoroacetate

Chemical Property:

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Technology Process of (6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(piperazin-1-yl)methanone trifluoroacetate

There total 9 articles about (6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(piperazin-1-yl)methanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₈FN₃O₄

: 76-05-1
trifluoroacetic acid

: 1355052-37-7
(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(piperazin-1-yl)methanone trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 371-41-5
4-Fluorophenol

: 1355052-37-7
(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(piperazin-1-yl)methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C

3.1: sodium nitrite; sulfuric acid / 1,2-dimethoxyethane; water / 0.83 h / 0 - 5 °C

3.2: 0.5 h / 0 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere

6.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 60 °C

6.2: pH 2 / Cooling with ice

7.1: dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

8.1: dichloromethane / 1 h / 20 °C

With sulfuric acid; tetrabutyl ammonium fluoride; water; hydrogen; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; sodium nitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 36160-82-4
4-(4-fluorophenoxy)aniline

: 1355052-37-7
(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(piperazin-1-yl)methanone trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium nitrite; sulfuric acid / 1,2-dimethoxyethane; water / 0.83 h / 0 - 5 °C

1.2: 0.5 h / 0 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere

4.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 60 °C

4.2: pH 2 / Cooling with ice

5.1: dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6.1: dichloromethane / 1 h / 20 °C

With sulfuric acid; tetrabutyl ammonium fluoride; water; potassium acetate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; sodium nitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;