36160-82-4

Basic information

• Product Name: 4-(4-FLUOROPHENOXY)ANILINE
• Synonyms: TIMTEC-BB SBB009577;SALOR-INT L300837-1EA;4-(4-FLUOROPHENOXY)ANILINE;4-(4-FLUOROPHENOXY)BENZENAMINE;AKOS B021931;ART-CHEM-BB B021931;Benzenamine, 4-(4-fluorophenoxy)-;4-Amino-4'-fluorodiphenyl ether
• CAS NO: 36160-82-4
• Molecular Formula: C₁₂H₁₀FNO
• Molecular Weight: 203.21
• Product Categories: Amines;C11 to C38;Nitrogen Compounds
• Mol File: 36160-82-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 58.9-60.4
• Boiling Point: 317.2 °C at 760 mmHg
• Flash Point: 145.7 °C
• Appearance: /
• Density: 1.22 g/cm³
• Vapor Pressure: 0.00039mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-FLUOROPHENOXY)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-FLUOROPHENOXY)ANILINE(36160-82-4)
• EPA Substance Registry System: 4-(4-FLUOROPHENOXY)ANILINE(36160-82-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 36160-82-4(Hazardous Substances Data)

Usage

General Description

4-(4-fluorophenoxy)aniline is an organic chemical compound with the formula C12H10FNO. It is a pale yellow solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is also known as 4-amino-4'-fluorodiphenyl ether, and is used as a building block in the production of dyes, pigments, and other chemical products. 4-(4-FLUOROPHENOXY)ANILINE is classified as an aniline, which is a type of aromatic amine that is commonly used in the manufacture of dyes and pharmaceuticals. It is important to handle 4-(4-fluorophenoxy)aniline with care, as it is considered to be harmful if swallowed, inhaled, or in contact with skin, and it may cause skin and eye irritation.

InChI:InChI=1/C12H10FNO/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8H,14H2

Upstream product

• 2561-25-3 4-(4-fluorophenoxy)-1-nitrobenzene 
• 371-41-5 4-Fluorophenol 
• 106-40-1 4-bromo-aniline 
• 100-00-5 4-chlorobenzonitrile 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 73944-70-4 3-{[4-(4-Fluoro-phenoxy)-phenylamino]-methyl}-3H-benzothiazole-2-thione 
• 73944-67-9 3-{[4-(4-Fluoro-phenoxy)-phenylamino]-methyl}-6-nitro-3H-benzooxazol-2-one 
• 73944-76-0 2-{[4-(4-Fluoro-phenoxy)-phenylamino]-methyl}-5-nitro-isoindole-1,3-dione 
• 38695-10-2 [4-(4-fluorophenoxy)phenyl]-N,N-dimethylamine 
• 129121-41-1 2-amino-6-(4'-fluorophenoxy)-benzothiazole 
• 442548-47-2 8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid [4-(4-fluoro-phenoxy)-phenyl]-amide 
• 73944-72-6 Benzotriazol-1-ylmethyl-[4-(4-fluoro-phenoxy)-phenyl]-amine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY

The present invention provides a novel heterocyclic compound represented by Formula [I] and a salt thereof: wherein the symbols are as defined in the specification, which is useful for treating, preventing and/or diagnosing seizure and the like in disease involving epileptic seizure or convulsive seizure (including multiple drug resistant seizure, refractory seizure, acute symptomatic seizure, febrile seizure and status epilepticus), as well as a medical use therefor.

Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels

Both N- and T-type calcium ion channels have been implicated in pain transmission and the N-type channel is a well-validated target for the treatment of neuropathic pain. An SAR investigation of a series of substituted aminobenzothiazoles identified a subset of five compounds with comparable activity to the positive control Z160 in a FLIPR-based intracellular calcium response assay measuring potency at both CaV2.2 and CaV3.2 channels. These compounds may form the basis for the development of drug leads and tool compounds for assessing in vivo effects of variable modulation of CaV2.2 and CaV3.2 channels.

Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors

Structure-based virtual screening of a commercial library identified pentanedioic acid derivatives (6 and 13b) as a kind of novel scaffold farnesyltransferase inhibitors (FTIs). Chemical modifications of the lead compounds, biological assays and analysis of the structure-activity relationships (SAR) were conducted to discover more potent FTIs. Some of them displayed excellent inhibition against FTase, and among them, the most active compound 13n with an IC50 value of 0.0029 μM and SAR analysis might be helpful to the discovery of more potent FTIs. This journal is