(R)-2-{(1R,4aS,5R,8aR)-5-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-7-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butyric acid

Base Information

Chemical Name:(R)-2-{(1R,4aS,5R,8aR)-5-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-7-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butyric acid
CAS No.:1028255-36-8
Molecular Formula:C₂₇H₃₈O₅
Molecular Weight:442.596
Hs Code.:

Synonyms:(R)-2-{(1R,4aS,5R,8aR)-5-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-7-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butyric acid

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Chemical Property of (R)-2-{(1R,4aS,5R,8aR)-5-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-7-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butyric acid

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Technology Process of (R)-2-{(1R,4aS,5R,8aR)-5-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-7-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butyric acid

There total 3 articles about (R)-2-{(1R,4aS,5R,8aR)-5-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-7-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 831221-71-7
(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyric acid

: 1028255-36-8
(R)-2-{(1R,4aS,5R,8aR)-5-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-7-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butyric acid

Guidance literature:: With hydrogenchloride; In acetone; at 20 ℃;
DOI:10.1021/jo0484575

Reference yield:

: 583866-26-6
(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butan-1-ol

: 1028255-36-8
(R)-2-{(1R,4aS,5R,8aR)-5-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-7-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - -40 °C

2: aq. NaClO₂; NaH₂PO₄*H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol; acetonitrile / 0.5 h / 0 °C

3: aq. HCl / acetone / 20 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; acetone; acetonitrile; tert-butyl alcohol; 1: Swern oxidation;
DOI:10.1021/jo0484575

Reference yield:

: 831221-70-6
(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyraldehyde

: 1028255-36-8
(R)-2-{(1R,4aS,5R,8aR)-5-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-7-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaClO₂; NaH₂PO₄*H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol; acetonitrile / 0.5 h / 0 °C

2: aq. HCl / acetone / 20 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In acetone; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo0484575