(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyric acid

Base Information Edit

Chemical Name:(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyric acid
CAS No.:831221-71-7
Molecular Formula:C₂₉H₄₂O₆
Molecular Weight:486.649
Hs Code.:
Mol file:831221-71-7.mol

(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyric acid

Synonyms:(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyric acid

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Chemical Property of (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyric acid Edit

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Technology Process of (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyric acid

There total 2 articles about (R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 831221-70-6
(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyraldehyde

: 831221-71-7
(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyric acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In acetonitrile; tert-butyl alcohol; at 0 ℃; for 0.5h;
DOI:10.1021/jo0484575

Reference yield:

: 583866-26-6
(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butan-1-ol

: 831221-71-7
(R)-2-{(4'R,4'aS,8'R,8'aR)-4'-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-6'-methyl-3',4',4'a,7',8',8'a-hexahydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalen]-8'-yl}-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - -40 °C

2: aq. NaClO₂; NaH₂PO₄*H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol; acetonitrile / 0.5 h / 0 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; acetonitrile; tert-butyl alcohol; 1: Swern oxidation;
DOI:10.1021/jo0484575