(E)-methyl 2-(2-(((2-(diethylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-3-methoxyacrylate

Base Information

Chemical Name:(E)-methyl 2-(2-(((2-(diethylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-3-methoxyacrylate
CAS No.:145910-89-0
Molecular Formula:C₂₁H₂₄F₃N₃O₃
Molecular Weight:423.435
Hs Code.:

Synonyms:(E)-methyl 2-(2-(((2-(diethylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-3-methoxyacrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-methyl 2-(2-(((2-(diethylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-3-methoxyacrylate

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Technology Process of (E)-methyl 2-(2-(((2-(diethylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-3-methoxyacrylate

There total 2 articles about (E)-methyl 2-(2-(((2-(diethylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-3-methoxyacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 117428-51-0
methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate

: 55545-81-8
2-N,N-Diethylamino-6-trifluoromethylpyrimidine-4-ol

: 145910-89-0
(E)-methyl 2-(2-(((2-(diethylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-3-methoxyacrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;
DOI:10.1016/j.bmcl.2013.04.045

Reference yield:

: 18240-93-2
1,1-diethylguanidine

: 145910-89-0
(E)-methyl 2-(2-(((2-(diethylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-3-methoxyacrylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

With sodium methylate; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.04.045