18240-93-2

Usage

Uses

Used in Pharmaceutical Industry:
N,N-Diethyl-guanidine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its strong basic properties and reactivity make it suitable for the production of drugs with specific therapeutic effects.
Used in Pesticide Industry:
In the pesticide industry, N,N-Diethyl-guanidine is utilized as a component in the formulation of various agrochemicals. Its ability to react with other chemicals allows for the creation of effective pest control agents.
Used in Rubber Industry:
N,N-Diethyl-guanidine is used as a rubber accelerator, enhancing the vulcanization process and improving the physical properties of rubber products. Its strong basic nature contributes to the acceleration of the curing process.
Used in Polymer Industry:
As a catalyst and stabilizer in the polymer industry, N,N-Diethyl-guanidine plays a crucial role in the production of various polymers. It aids in the polymerization process and helps to stabilize the resulting polymers, ensuring their quality and performance.

InChI:InChI=1/C5H13N3/c1-3-8(4-2)5(6)7/h3-4H2,1-2H3,(H3,6,7)

Upstream product

• 420-04-2 CYANAMID 
• 660-68-4 diethyl amine hydrochloride 
• 634-95-7 N,N-diethylurea 
• 53114-57-1 S-methylisothiourea hydrochloride 
• 109-89-7 diethylamine 
• 147895-43-0 S-methylisothiourea hemisulphate 
• 2986-19-8 carbamimidothioic acid methyl ester 
• 161331-40-4 N,N'-diethyl-S-methyl-isothiourea 
• 7664-41-7 ammonia 
• 27096-30-6 diethylammonium, NO₃^(1-)-salt 
• 867-44-7 S-Methylisothiourea sulfate 
• 127099-85-8 N-Cyanoguanidine 
• 617-83-4 Diethylcyanamide 

Downstream Products

• 1338250-44-4 C₂₉H₂₇N₇ 
• 1338250-45-5 C₃₀H₂₉N₇ 
• 1338250-46-6 C₂₉H₂₆FN₇ 
• 1338250-47-7 C₂₉H₂₆ClN₇ 
• 145910-89-0 (E)-methyl 2-(2-(((2-(diethylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-3-methoxyacrylate 
• 42487-72-9 2-diethylamino-4-hydroxy-6-methyl-pyrimidine 
• 1441961-34-7 2-(ethylamino)-4,6-diphenylpyrimidine-5-carbonitrile 

Relevant academic research and scientific papers

Continuous synthesis method of hydroxypyrimidine compound

The invention discloses a continuous synthesis method of a hydroxypyrimidine compound. The method comprises the steps: carrying out continuous reaction on organic amine and a 50% cyanamide aqueous solution in a micro-reactor, introducing the reaction solution into a liquid separator for continuous phase splitting, carrying out continuous ring closing on a guanidine solution and alpha-alkyl acetoacetate in a second micro-reactor, washing the reaction solution with water, and desolventizing to obtain a target product. The method is based on the concept of green chemistry, the comprehensive costof raw materials is far lower than that of traditional methods, no salt-containing wastewater is generated, and treatment is easy; traditional solid-liquid separation is avoided, automatic productionis facilitated, and the safety and environmental protection level of the device is improved; continuous synthesis is adopted, decomposition of an intermediate is avoided, the total yield is larger than 82%, and the product content reaches 98%.

Synthesis of novel strobilurin-pyrimidine derivatives and their antiproliferative activity against human cancer cell lines

A series of new strobilurin-pyrimidine analogs were designed and synthesized based on the structures of our previously discovered antiproliferative compounds I and II. Biological evaluation with two human cancer cell lines (A549 and HL60) showed that most of these compounds possessed moderate to potent antiproliferative activity. Two potent candidates (8f, IC50 = 2.2 nM and 11d, IC50 = 3.4 nM) were identified with nanomolar activity against leukemia cancer cell line HL60 for further development. This activity represents a 1000- to 2500-fold improvement compared to the parent compounds I and II and is 20- to 30-fold better than the chemotherapy drug, doxorubicin. The present work provides strong incentive for further development of these strobilurin-pyrimidine analogs as potential antitumor agents for the treatment of leukemia.

Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c] quinoline derivatives

A series of 2,5-disubstituted pyrimido[5,4-c]quinoline derivatives were synthesized and their cytotoxic activity against H460, HT-29 and MDA-MB-231 cell lines was evaluated in vitro. It was found that most of the tested compounds especially compound 17, s

Wrinkle-care product

A wrinkle-care product, an aging-preventive cosmetic and a skin cosmetic each comprising a guanidine derivative of formula (I) or an acid addition salt thereof: STR1 wherein R1 represents a hydrogen atom, a lower alkyl group or --(AO)m --(BO)n --D--E ?wherein A and B may be the same or different and each represents an alkylene group having 2 to 8 carbon atoms; D represents a binding hand, --CO--, or an unsubstituted or substituted alkylene group having 1 to 6 carbon atoms; E represents a hydrogen atom, a lower alkyl group, an aralkyl group or an unsubstituted or substituted aryl group; m is a number of from 1 to 6; and n is a number of from 0 to 6!; k is a number of from 1 to 10; and G represents a hydrogen atom, a hydroxyl group, a carboxyl group, a sulfonate group or a phosphate group. These products are excellent in the effects of inhibiting wrinkling and smoothing wrinkles without damaging the physiological conditions of the skin.