N-{1-[(E)-3-Methoxy-phenylimino]-ethyl}-4-methyl-N-(4-nitro-phenyl)-benzenesulfonamide

Base Information

• Chemical Name: N-{1-[(E)-3-Methoxy-phenylimino]-ethyl}-4-methyl-N-(4-nitro-phenyl)-benzenesulfonamide
• CAS No.: 134899-60-8
• Molecular Formula: C₂₂H₂₁N₃O₅S
• Molecular Weight: 439.492
• Mol file: 134899-60-8.mol

Synonyms:N-{1-[(E)-3-Methoxy-phenylimino]-ethyl}-4-methyl-N-(4-nitro-phenyl)-benzenesulfonamide

Chemical Property of N-{1-[(E)-3-Methoxy-phenylimino]-ethyl}-4-methyl-N-(4-nitro-phenyl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{1-[(E)-3-Methoxy-phenylimino]-ethyl}-4-methyl-N-(4-nitro-phenyl)-benzenesulfonamide

There total 2 articles about N-{1-[(E)-3-Methoxy-phenylimino]-ethyl}-4-methyl-N-(4-nitro-phenyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

N-tosyl-p-nitro-aniline sodium salt (128799-92-8) + m-Methoxyacetophenoxime tosylate → N-{1-[(E)-3-Methoxy-phenylimino]-ethyl}-4-methyl-N-(4-nitro-phenyl)-benzenesulfonamide (134899-60-8)

Guidance literature:

In tetrahydrofuran; for 2h; Heating;

DOI:10.1248/cpb.39.558

Reference yield:

1-(3-methoxy-phenyl)-ethanone oxime (122806-25-1) → N-{1-[(E)-3-Methoxy-phenylimino]-ethyl}-4-methyl-N-(4-nitro-phenyl)-benzenesulfonamide (134899-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 24 h / ice box

2: 53 percent / tetrahydrofuran / 2 h / Heating

With triethylamine; In tetrahydrofuran;

DOI:10.1248/cpb.39.558

Reference yield:

ethanol (64-17-5) + N-{1-[(E)-3-Methoxy-phenylimino]-ethyl}-4-methyl-N-(4-nitro-phenyl)-benzenesulfonamide (134899-60-8) → N-(4-nitrophenyl)-4-methylbenzenesulfonamide (734-25-8) + Ethyl N-(m-methoxyphenyl)acetimidate (134899-79-9)

Guidance literature:

With sodium ethanolate; In tetrahydrofuran; ethanol; at 25 ℃; Rate constant; Mechanism; variation of NaOEt-concentration;

DOI:10.1248/cpb.39.558

upstream raw materials:

N-tosyl-p-nitro-aniline sodium salt

1-(3-methoxy-phenyl)-ethanone oxime

Downstream raw materials:

N-(4-nitrophenyl)-4-methylbenzenesulfonamide

Ethyl N-(m-methoxyphenyl)acetimidate