(R)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide

Base Information

• Chemical Name: (R)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide
• CAS No.: 1424357-10-7
• Molecular Formula: C₂₃H₂₁F₃NOP
• Molecular Weight: 415.395
• Mol file: 1424357-10-7.mol

Synonyms:(R)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide

Chemical Property of (R)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide

There total 3 articles about (R)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ (R)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide (1424357-10-7)

Guidance literature:

With methanol; (S)-N-(3-(tert-butyl)-2-hydroxybenzyl)-1-(dimethylamino)-3-methyl-1-oxobutan-2-aminium; sodium t-butanolate; In toluene; at 22 ℃; for 4h; Inert atmosphere;

With sodium periodate; water; In toluene; for 0.333333h;

Reference yield: 92.0%

P,P-diphenyl-N-(4-(trifluoromethyl)benzylidene)phosphinic amide (207222-25-1) + 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (72824-04-5) → (R)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide (1424357-10-7)

Guidance literature:

With (S)-N-(3-(tert-butyl)-2-hydroxybenzyl)-1-(dimethylamino)-3-methyl-1-oxobutan-2-aminium; sodium t-butanolate; In methanol; toluene; at 22 ℃; for 4h; enantioselective reaction; Inert atmosphere;

DOI:10.1038/nature11844

Reference yield:

2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (72824-04-5) + (E)-N-(4-(trifluoromethyl)benzylidene)-P,P-diphenylphosphinic amide (98837-45-7) → (S)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide (1273587-66-8) + (R)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide (1424357-10-7)

Guidance literature:

With methanol; (S)-N-(3-(tert-butyl)-2-hydroxybenzyl)-1-(dimethylamino)-3-methyl-1-oxobutan-2-aminium; sodium t-butanolate; In toluene; at 22 ℃; for 4h; Overall yield = 93 %; Inert atmosphere;

upstream raw materials:

P,P-diphenyl-N-(4-(trifluoromethyl)benzylidene)phosphinic amide

2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

(E)-N-(4-(trifluoromethyl)benzylidene)-P,P-diphenylphosphinic amide