(E)-N-(4-(trifluoromethyl)benzylidene)-P,P-diphenylphosphinic amide

Base Information

• Chemical Name: (E)-N-(4-(trifluoromethyl)benzylidene)-P,P-diphenylphosphinic amide
• CAS No.: 98837-45-7
• Molecular Formula: C₂₀H₁₅F₃NOP
• Molecular Weight: 373.314
• Mol file: 98837-45-7.mol

Synonyms:(E)-N-(4-(trifluoromethyl)benzylidene)-P,P-diphenylphosphinic amide

Chemical Property of (E)-N-(4-(trifluoromethyl)benzylidene)-P,P-diphenylphosphinic amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(4-(trifluoromethyl)benzylidene)-P,P-diphenylphosphinic amide

There total 5 articles about (E)-N-(4-(trifluoromethyl)benzylidene)-P,P-diphenylphosphinic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-(trifluoromethyl)benzaldehyde oxime (66046-34-2) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → (E)-N-(4-(trifluoromethyl)benzylidene)-P,P-diphenylphosphinic amide (98837-45-7)

Guidance literature:

4-(trifluoromethyl)benzaldehyde oxime; With triethylamine; In hexane; dichloromethane; at -40 ℃; for 0.166667h; Inert atmosphere;

chloro-diphenylphosphine; In hexane; dichloromethane; at -40 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1016/j.tet.2014.12.063

Reference yield:

(E)-4-(trifluoromethyl)benzaldoxime (16939-49-4,24652-60-6,66046-34-2) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → (E)-N-(4-(trifluoromethyl)benzylidene)-P,P-diphenylphosphinic amide (98837-45-7)

Guidance literature:

With triethylamine; In dichloromethane; 1.) -40 to -45 deg C, 3 h; 2.) ambient temperature, 2 h;

DOI:10.1039/P29880001145

Reference yield:

diphenylphosphinamide (5994-87-6) → (E)-N-(4-(trifluoromethyl)benzylidene)-P,P-diphenylphosphinic amide (98837-45-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-(chlorosulfinyl)imidazole / CH₂Cl₂ / 6 h / 20 °C

2: toluene / 16 h / 20 °C

With N-(chlorosulfinyl)imidazole; In dichloromethane; toluene;

DOI:10.1021/jo051491e

upstream raw materials:

(E)-4-(trifluoromethyl)benzaldoxime

chloro-diphenylphosphine

4-Trifluoromethylbenzaldehyde

C₁₂H₁₀NO₂PS

Downstream raw materials:

(S)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide

(R)-P,P-diphenyl-N-(1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)phosphinic amide

2-(diphenylphosphinoyl)-3-(4-trifluoromethylphenyl)oxaziridine