mono<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl> *,S)>butanedioate

Base Information

• Chemical Name: mono<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl> *,S)>butanedioate
• CAS No.: 130406-50-7
• Molecular Formula: C₃₆H₄₃N₃O₇
• Molecular Weight: 629.753

Synonyms:mono<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl> *,S)>butanedioate

Chemical Property of mono<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl> *,S)>butanedioate

Chemical Property:

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Safty Information:

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Technology Process of mono<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl> *,S)>butanedioate

There total 4 articles about mono<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl> *,S)>butanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

succinic acid anhydride (108-30-5) + PD 132458 (130406-47-2) → mono<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl> *,S)>butanedioate (130406-50-7)

Guidance literature:

With dmap; In ethyl acetate; for 24h; Heating;

DOI:10.1021/jm00105a062

Reference yield:

1-adamantanol (700-57-2) → mono<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl> *,S)>butanedioate (130406-50-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: 89 percent / Et₃N / tetrahydrofuran / 0.25 h

3: 90 percent / LiOH / H₂O; dioxane / 18 h / Ambient temperature

4: 1.) C₆F₅OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 18 h, 2.) 48 h

5: 98 percent / 4-(dimethylamino)pyridine / ethyl acetate / 24 h / Heating

With pyridine; dmap; lithium hydroxide; 2,3,4,5,6-pentafluorophenol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate;

DOI:10.1021/jm00105a062

Reference yield:

N-[(2-adamantyloxy)-carbonyl]-α-methyl-R-tryptophane (130406-40-5) → mono<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl> *,S)>butanedioate (130406-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) C₆F₅OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 18 h, 2.) 48 h

2: 98 percent / 4-(dimethylamino)pyridine / ethyl acetate / 24 h / Heating

With dmap; 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide; In ethyl acetate;

DOI:10.1021/jm00105a062

upstream raw materials:

succinic acid anhydride

PD 132458

1-adamantanol

N-[(2-adamantyloxy)-carbonyl]-α-methyl-R-tryptophane

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