methyl (S)-4-(tret-butyldimethylsilyloxy)-5-(4-methoxybenzylamino)-5-oxopentanoate

Base Information

Chemical Name:methyl (S)-4-(tret-butyldimethylsilyloxy)-5-(4-methoxybenzylamino)-5-oxopentanoate
CAS No.:908040-19-7
Molecular Formula:C₂₀H₃₃NO₅Si
Molecular Weight:395.571
Hs Code.:

Synonyms:methyl (S)-4-(tret-butyldimethylsilyloxy)-5-(4-methoxybenzylamino)-5-oxopentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (S)-4-(tret-butyldimethylsilyloxy)-5-(4-methoxybenzylamino)-5-oxopentanoate

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Technology Process of methyl (S)-4-(tret-butyldimethylsilyloxy)-5-(4-methoxybenzylamino)-5-oxopentanoate

There total 2 articles about methyl (S)-4-(tret-butyldimethylsilyloxy)-5-(4-methoxybenzylamino)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 908040-18-6
methyl (S)-4-hydroxy-5-(4-methoxybenzylamino)-5-oxopentanoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 908040-19-7
methyl (S)-4-(tret-butyldimethylsilyloxy)-5-(4-methoxybenzylamino)-5-oxopentanoate

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2006.05.013

Reference yield:

: 562817-52-1
(S)-N-(4-methoxybenzyl)-tetrahydro-5-oxo-2-furancarboxamide

: 908040-19-7
methyl (S)-4-(tret-butyldimethylsilyloxy)-5-(4-methoxybenzylamino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / H₂SO₄ / 1.5 h / 20 °C

2: 92 percent / imidazole; DMAP / dimethylformamide / 3 h / 20 °C

With 1H-imidazole; dmap; sulfuric acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.05.013