rac-1-[trans-2-(4-aminocyclohexyl)-2-hydroxyethyl]-7-methoxy-1H-quinolin-2-one

Base Information

Chemical Name:rac-1-[trans-2-(4-aminocyclohexyl)-2-hydroxyethyl]-7-methoxy-1H-quinolin-2-one
CAS No.:1198355-06-4
Molecular Formula:C₁₈H₂₄N₂O₃
Molecular Weight:316.4
Hs Code.:

Synonyms:rac-1-[trans-2-(4-aminocyclohexyl)-2-hydroxyethyl]-7-methoxy-1H-quinolin-2-one

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Chemical Property of rac-1-[trans-2-(4-aminocyclohexyl)-2-hydroxyethyl]-7-methoxy-1H-quinolin-2-one

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Technology Process of rac-1-[trans-2-(4-aminocyclohexyl)-2-hydroxyethyl]-7-methoxy-1H-quinolin-2-one

There total 4 articles about rac-1-[trans-2-(4-aminocyclohexyl)-2-hydroxyethyl]-7-methoxy-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1198355-05-3
rac-{trans-4-[hydroxy-(7-methoxy-2-oxo-2H-quinolin-1-yl)methyl]cyclohexyl}carbamic acid tert-butyl ester

: 1198355-06-4
rac-1-[trans-2-(4-aminocyclohexyl)-2-hydroxyethyl]-7-methoxy-1H-quinolin-2-one

Guidance literature:: rac-{trans-4-[hydroxy-(7-methoxy-2-oxo-2H-quinolin-1-yl)methyl]cyclohexyl}carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.333333h;

With sodium hydrogencarbonate; sodium hydroxide; In water;

Reference yield:

: 1198355-04-2
rac-{trans-4-[2-(7-methoxy-2-oxo-2H-quinolin-1-yl)acetyl]cyclohexyl}carbamic acid tert-butyl ester

: 1198355-06-4
rac-1-[trans-2-(4-aminocyclohexyl)-2-hydroxyethyl]-7-methoxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h

2: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

With sodium tetrahydroborate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1198355-03-1
trans-[4-(2-bromoacetyl)cyclohexyl]carbamic acid tert-butyl ester

: 1198355-06-4
rac-1-[trans-2-(4-aminocyclohexyl)-2-hydroxyethyl]-7-methoxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 75 °C

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h

3: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

With sodium tetrahydroborate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;