rac-{trans-4-[1-azido-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]cyclohexyl}carbamic acid benzyl ester

Base Information

Chemical Name:rac-{trans-4-[1-azido-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]cyclohexyl}carbamic acid benzyl ester
CAS No.:1198355-09-7
Molecular Formula:C₂₆H₂₉N₅O₄
Molecular Weight:475.547
Hs Code.:

Synonyms:rac-{trans-4-[1-azido-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]cyclohexyl}carbamic acid benzyl ester

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Chemical Property of rac-{trans-4-[1-azido-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]cyclohexyl}carbamic acid benzyl ester

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Technology Process of rac-{trans-4-[1-azido-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]cyclohexyl}carbamic acid benzyl ester

There total 7 articles about rac-{trans-4-[1-azido-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]cyclohexyl}carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1198355-08-6
rac-methanesulfonic acid trans-1-(4-benzyloxycarbonylamino-cyclohexyl)-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl ester

: 1198355-09-7
rac-{trans-4-[1-azido-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]cyclohexyl}carbamic acid benzyl ester

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield:

: 1198355-04-2
rac-{trans-4-[2-(7-methoxy-2-oxo-2H-quinolin-1-yl)acetyl]cyclohexyl}carbamic acid tert-butyl ester

: 1198355-09-7
rac-{trans-4-[1-azido-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]cyclohexyl}carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h

2: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

3: sodium hydrogencarbonate / water; acetone / 0 - 20 °C

4: triethylamine / dichloromethane / 0.5 h

5: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C

With sodium tetrahydroborate; sodium azide; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1198355-07-5
trans-{4-[(1RS)-1-hydroxy-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]cyclohexyl}carbamic acid benzyl ester

: 1198355-09-7
rac-{trans-4-[1-azido-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]cyclohexyl}carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h

2: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C

With sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;